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High-Fat Diet Induced Obesity Increases Serum Myostatin, but Does Not Accelerate Skeletal Muscle Atrophy
(East Carolina University, 2013)
Myostatin is a potent negative regulator of muscle mass, i.e. high levels of myostatin induce loss of muscle. Surprisingly, severely obese humans and obese mice have elevated levels of serum myostatin, but the role of ...
Increased Antagonist Coactivation-Related Hamstring Torque Reduces Maximal Knee Extension Torque in Healthy Old Adults
(East Carolina University, 2010)
As humans age, the ability to produce maximal voluntary torque decreases due to muscle atrophy (sarcopenia) and it is also known that advancing age alters the neural control of voluntary movement. One manifestation of the ...
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle
(East Carolina University, 2013)
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology ...
AMP Deaminase 3 in Skeletal Muscle Atrophy: Regulation of Protein Degradation and Contractile Performance
(East Carolina University, 2015-11-23)
Skeletal muscle atrophy is characterized by depressed cellular energetics, increased rates of protein degradation, contractile deficits and loss of muscle mass. A potential regulator of these impairments is the metabolic ...
Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice
(2015-11-04)
Background:
A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a diet alters the ability to respond to atrophy signals. ...
AMP Deaminase 3 knockout mice and loss of mitochondrial proteins and enzyme activity during denervation atrophy
(East Carolina University, 2018-07-17)
Muscle atrophy leads to decrements in muscle function, partly attributable to decreased mitochondrial content. One controller of mitochondrial content is AMP-activated protein kinase (AMPK), which when bound by AMP activates ...
Paired Effects of Dietary Leucine Supplementation and Overload on Protein Translational Signaling and Hypertrophy in Aged Rat Skeletal Muscle
(East Carolina University, 2012)
Sarcopenia is an age-associated disorder that causes loss of skeletal muscle mass, particularly in type II (fast-twitch) muscle fibers. This loss in muscle mass can cause disability, reductions in the quality of life, and ...