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Mouse Strain Dependent Differences in Muscle Fiber Type, Fiber Area, and Blood Perfusion in Response to Denervation Atrophy
(East Carolina University, 1/13/16)
Skeletal muscle atrophy caused by denervation is a serious consequence of neuropathic disease, especially diabetes. However, the only proven treatment for muscle atrophy is exercise, which can be difficult or impossible ...
AMP Deaminase 3 knockout mice and loss of mitochondrial proteins and enzyme activity during denervation atrophy
(East Carolina University, 2018-07-17)
Muscle atrophy leads to decrements in muscle function, partly attributable to decreased mitochondrial content. One controller of mitochondrial content is AMP-activated protein kinase (AMPK), which when bound by AMP activates ...