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Unravelling the mechanisms of menopause-induced insulin resistance: novel roles for estradiol in skeletal muscle mitochondrial function
(East Carolina University, 2016-11-16)
Menopause results in a progressive decline in ovarian production of 17[beta]-estradiol (E2), increased adiposity and a higher risk for type-2 diabetes, but hormone replacement therapies containing E2 reverse most of these ...
ELUCIDATION ON THE MECHANISM OF CAMKKα AS A PRO-GROWTH KINASE IN MOUSE SKELETAL MUSCLE
(East Carolina University, 2016-12-15)
Type 2 diabetes affects ~25 million people in the U.S., and is the primary cause of non-traumatic lower limb amputation and the leading cause of blindness in adults. Major risk factors for the development of type 2 diabetes ...
Peroxisomal-Mitochondrial Metabolic Interactions in Lipid Metabolism in Human Skeletal Muscle
(East Carolina University, 2016-11-16)
Peroxisomal activity and associated functions, including [beta]-oxidation contributions toward maintaining cellular lipid homeostasis, is poorly defined in extra hepatic tissues, most especially in human skeletal muscle ...
Effect of previous hamstring strain on Anterior Cruciate Ligament (ACL) forces
(East Carolina University, 2016-08-18)
Introduction: Anterior Cruciate Ligament (ACL) injuries are very common in the athletic population. While the hamstring muscles help protect the ACL, hamstring strain injuries (HSI) are also common in sports. After HSI, ...
Identifying Primary Healthcare Providers’ Barriers to Prescribing Physical Activity as Medicine in Comparison to their own Physical Activity Level
(East Carolina University, 2016-06-01)
Abstract Objective. To examine healthcare providers' barriers to counseling physical activity to their patients. Then examine the same primary providers' own physical activity level over the course of 7 days (1 week) using ...
Effects of High-Insulin Exposure on Mitochondrial Content in Skeletal Muscle Myotubes from Lean & Severely Obese Individuals: A Time Course Analysis
(East Carolina University, 2016-08-01)
Skeletal muscle is the site at which highly regulated energetic processes take place as a means of maintaining both tissue-specific and whole-body metabolism. With the development of severe obesity (BMI [greater-than] or ...
Substrate Utilization During Submaximal Exercise in Children with a Severely Obese Mother and Response to Exercise Training
(East Carolina University, 2016-08-18)
The aim of this study was to compare fat metabolism during submaximal exercise in children with a severely obese mother (BMI[greater than or equal to]35 kg/m2) to children with a lean, non-obese mother (BMI[less than or ...
Alterations in insulin action and contraction-mediated metabolism in myotubes derived from Roux-en-Y gastric bypass patients
(5/16/2016)
Roux-en-Y gastric bypass (RYGB) surgery induces various metabolic benefits in severely obese (BMI> 40 kg/m2) individuals, including improved insulin action in peripheral tissues, most notably skeletal muscle, and remission ...