Acute Modulation of Adipose Tissue Lipolysis by Intravenous Estrogens
Author
Van Pelt, Rachael E.; Gozansky, Wendolyn S.; Hickner, Robert C.; Schwartz, Robert S.; Kohrt, Wendy M.
Abstract
Objective: The aim of this study was to determine whether intravenous (IV) conjugated estrogens (EST) acutely enhance the suppression of whole-body or regional subcutaneous adipose tissue (SAT) lipolysis by insulin in postmenopausal women. Research Methods and Procedures: We assessed whole-body lipolysis by [2H5]glycerol rate of appearance (GlycRA) and abdominal and femoral SAT lipolysis (interstitial glycerol; GlycIS) by subcutaneous microdialysis. Postmenopausal women (n = 12) were studied on two occasions, with IV EST or saline control (CON), under basal conditions and during a 3-stage (4, 8, and 40 mU/m2/ min) hyperinsulinemic, euglycemic clamp. Ethanol outflow/inflow ratio and recovery of [13C] glycerol during microdialysis were used to assess blood flow changes and interstitial glycerol concentrations, respectively. Results: Compared with CON, EST did not affect systemic basal or insulin-mediated suppression of lipolysis (GlycRA) or SAT nutritive blood flow. Basal GlycIS in SAT was reduced on the EST day. However, insulin-mediated suppression of lipolysis in SAT was not significantly influenced by EST. Discussion: These findings suggest that estrogens acutely reduce basal lipolysis in SAT through an unknown mechanism but do not alter whole-body or SAT suppression of lipolysis by insulin. Originally published Obesity (Silver Spring), Vol. 14, No. 12, Dec 2006
Date
2006-12
Citation:
APA:
Van Pelt, Rachael E., & Gozansky, Wendolyn S., & Hickner, Robert C., & Schwartz, Robert S., & Kohrt, Wendy M.. (December 2006).
Acute Modulation of Adipose Tissue Lipolysis by Intravenous Estrogens.
Obesity (Silver Spring),
14(12),
2163-
2172. Retrieved from
http://hdl.handle.net/10342/3141
MLA:
Van Pelt, Rachael E., and Gozansky, Wendolyn S., and Hickner, Robert C., and Schwartz, Robert S., and Kohrt, Wendy M..
"Acute Modulation of Adipose Tissue Lipolysis by Intravenous Estrogens". Obesity (Silver Spring).
14:12. (2163-2172),
December 2006.
September 27, 2023.
http://hdl.handle.net/10342/3141.
Chicago:
Van Pelt, Rachael E. and Gozansky, Wendolyn S. and Hickner, Robert C. and Schwartz, Robert S. and Kohrt, Wendy M.,
"Acute Modulation of Adipose Tissue Lipolysis by Intravenous Estrogens," Obesity (Silver Spring) 14, no.
12 (December 2006),
http://hdl.handle.net/10342/3141 (accessed
September 27, 2023).
AMA:
Van Pelt, Rachael E., Gozansky, Wendolyn S., Hickner, Robert C., Schwartz, Robert S., Kohrt, Wendy M..
Acute Modulation of Adipose Tissue Lipolysis by Intravenous Estrogens. Obesity (Silver Spring).
December 2006;
14(12):
2163-2172.
http://hdl.handle.net/10342/3141. Accessed
September 27, 2023.
Collections
Publisher
East Carolina University