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    Review of microdialysis in brain tumors, from concept to application: First Annual Carolyn Frye-Halloran Symposium

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    Author
    Benjamin, Ramsis K.; Hochberg, Fred H.; Fox, Elizabeth; Bungay, Peter M.; Elmquist, William F.; Stewart, Clinton F.; Gallo, James M.; Collins, Jerry M.; Pelletier, Robert P.; de Groot, John F.; Hickner, Robert C.; Cavus, Idil; Grossman, Stuart A.; Colvin, O. Michael
    Abstract
    In individuals with brain tumors, pharmacodynamic and pharmacokinetic studies of therapeutic agents have historically used analyses of drug concentrations in serum or cerebrospinal fluid, which unfortunately do not necessarily reflect concentrations within the tumor and adjacent brain. This review article introduces to neurological and medical oncologists, as well as pharmacologists, the application of microdialysis in monitoring drug metabolism and delivery within the fluid of the interstitial space of brain tumor and its surroundings. Microdialysis samples soluble molecules from the extracellular fluid via a semipermeable membrane at the tip of a probe. In the past decade, it has been used predominantly in neurointensive care in the setting of brain trauma, vasospasm, epilepsy, and intracerebral hemorrhage. At the first Carolyn Frye-Halloran Symposium held at Massachusetts General Hospital in March 2002, the concept of microdialysis was extended to specifically address its possible use in treating brain tumor patients. In doing so we provide a rationale for the use of this technology by a National Cancer Institute consortium, New Approaches to Brain Tumor Therapy, to measure levels of drugs in brain tissue as part of phase 1 trials. Originally published Neuro-oncology, Vol. 6, No. 1, Jan 2004
    URI
    http://hdl.handle.net/10342/3216
    Subject
     Brain tumors; Microdialysis; Drug metabolism; Drug delivery 
    Date
    2004-01
    Citation:
    APA:
    Benjamin, Ramsis K., & Hochberg, Fred H., & Fox, Elizabeth, & Bungay, Peter M., & Elmquist, William F., & Stewart, Clinton F., & Gallo, James M., & Collins, Jerry M., & Pelletier, Robert P., & de Groot, John F., & Hickner, Robert C., & Cavus, Idil, & Grossman, Stuart A., & Colvin, O. Michael. (January 2004). Review of microdialysis in brain tumors, from concept to application: First Annual Carolyn Frye-Halloran Symposium. , (. Retrieved from http://hdl.handle.net/10342/3216

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Benjamin, Ramsis K., and Hochberg, Fred H., and Fox, Elizabeth, and Bungay, Peter M., and Elmquist, William F., and Stewart, Clinton F., and Gallo, James M., and Collins, Jerry M., and Pelletier, Robert P., and de Groot, John F., and Hickner, Robert C., and Cavus, Idil, and Grossman, Stuart A., and Colvin, O. Michael. "Review of microdialysis in brain tumors, from concept to application: First Annual Carolyn Frye-Halloran Symposium". . . (.), January 2004. March 07, 2021. http://hdl.handle.net/10342/3216.
    Chicago:
    Benjamin, Ramsis K. and Hochberg, Fred H. and Fox, Elizabeth and Bungay, Peter M. and Elmquist, William F. and Stewart, Clinton F. and Gallo, James M. and Collins, Jerry M. and Pelletier, Robert P. and de Groot, John F. and Hickner, Robert C. and Cavus, Idil and Grossman, Stuart A. and Colvin, O. Michael, "Review of microdialysis in brain tumors, from concept to application: First Annual Carolyn Frye-Halloran Symposium,"  , no. (January 2004), http://hdl.handle.net/10342/3216 (accessed March 07, 2021).
    AMA:
    Benjamin, Ramsis K., Hochberg, Fred H., Fox, Elizabeth, Bungay, Peter M., Elmquist, William F., Stewart, Clinton F., Gallo, James M., Collins, Jerry M., Pelletier, Robert P., de Groot, John F., Hickner, Robert C., Cavus, Idil, Grossman, Stuart A., Colvin, O. Michael. Review of microdialysis in brain tumors, from concept to application: First Annual Carolyn Frye-Halloran Symposium. . January 2004; () . http://hdl.handle.net/10342/3216. Accessed March 07, 2021.
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    • Kinesiology
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    East Carolina University

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