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    Transcriptional regulation of muscle fatty acid-binding protein.

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    Author
    Carey, Julie O.; Neufer, P. Darrell; Farrar, Roger P.; Veerkamp, Jacques H.; Dohm, G. Lynis
    Abstract
    Heart fatty acid-binding protein (H-FABP) is present in a wide variety of tissues but is found in the highest concentration in cardiac and red skeletal muscle. It has been proposed that the expression of H-FABP correlates directly with the fatty acid oxidative capacity of the tissue. In the present study, the expression of H-FABP was measured in red and white skeletal muscle under two conditions in which fatty acid utilization is known to be increased: streptozotocin-induced diabetes and fasting. Protein concentration, mRNA concentration and transcription rate were measured under both conditions. The level of both protein and mRNA increased approximately 2-fold under each condition. The transcription rate was higher in red skeletal muscle than in white muscle, was increased 2-fold during fasting, but was unchanged by streptozotocin-induced diabetes. In addition to supporting the hypothesis that H-FABP is induced during conditions of increased fatty acid utilization, these findings demonstrate that the regulation of H-FABP expression may or may not be at the level of transcription depending on the stimulus. Originally published Biochemical Journal, Vol. 298, Pt. 3, Mar 1994
    URI
    http://hdl.handle.net/10342/3246
    Subject
     H-FABP; Fatty acid utilization; Skeletal muscle 
    Date
    1994-03-15
    Citation:
    APA:
    Carey, Julie O., & Neufer, P. Darrell, & Farrar, Roger P., & Veerkamp, Jacques H., & Dohm, G. Lynis. (March 1994). Transcriptional regulation of muscle fatty acid-binding protein.. , (. Retrieved from http://hdl.handle.net/10342/3246

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Carey, Julie O., and Neufer, P. Darrell, and Farrar, Roger P., and Veerkamp, Jacques H., and Dohm, G. Lynis. "Transcriptional regulation of muscle fatty acid-binding protein.". . . (.), March 1994. July 07, 2022. http://hdl.handle.net/10342/3246.
    Chicago:
    Carey, Julie O. and Neufer, P. Darrell and Farrar, Roger P. and Veerkamp, Jacques H. and Dohm, G. Lynis, "Transcriptional regulation of muscle fatty acid-binding protein.,"  , no. (March 1994), http://hdl.handle.net/10342/3246 (accessed July 07, 2022).
    AMA:
    Carey, Julie O., Neufer, P. Darrell, Farrar, Roger P., Veerkamp, Jacques H., Dohm, G. Lynis. Transcriptional regulation of muscle fatty acid-binding protein.. . March 1994; () . http://hdl.handle.net/10342/3246. Accessed July 07, 2022.
    Collections
    • Kinesiology
    Publisher
    East Carolina University

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