Transcriptional regulation of muscle fatty acid-binding protein.
Author
Carey, Julie O.; Neufer, P. Darrell; Farrar, Roger P.; Veerkamp, Jacques H.; Dohm, G. Lynis
Abstract
Heart fatty acid-binding protein (H-FABP) is present in a wide variety of tissues but is found in the highest concentration in cardiac and red skeletal muscle. It has been proposed that the expression of H-FABP correlates directly with the fatty acid oxidative capacity of the tissue. In the present study, the expression of H-FABP was measured in red and white skeletal muscle under two conditions in which fatty acid utilization is known to be increased: streptozotocin-induced diabetes and fasting. Protein concentration, mRNA concentration and transcription rate were measured under both conditions. The level of both protein and mRNA increased approximately 2-fold under each condition. The transcription rate was higher in red skeletal muscle than in white muscle, was increased 2-fold during fasting, but was unchanged by streptozotocin-induced diabetes. In addition to supporting the hypothesis that H-FABP is induced during conditions of increased fatty acid utilization, these findings demonstrate that the regulation of H-FABP expression may or may not be at the level of transcription depending on the stimulus. Originally published Biochemical Journal, Vol. 298, Pt. 3, Mar 1994
Subject
Date
1994-03-15
Citation:
APA:
Carey, Julie O., & Neufer, P. Darrell, & Farrar, Roger P., & Veerkamp, Jacques H., & Dohm, G. Lynis. (March 1994).
Transcriptional regulation of muscle fatty acid-binding protein..
Biochemical Journal,
298(3),
613-
617. Retrieved from
http://hdl.handle.net/10342/3246
MLA:
Carey, Julie O., and Neufer, P. Darrell, and Farrar, Roger P., and Veerkamp, Jacques H., and Dohm, G. Lynis.
"Transcriptional regulation of muscle fatty acid-binding protein.". Biochemical Journal.
298:3. (613-617),
March 1994.
September 26, 2023.
http://hdl.handle.net/10342/3246.
Chicago:
Carey, Julie O. and Neufer, P. Darrell and Farrar, Roger P. and Veerkamp, Jacques H. and Dohm, G. Lynis,
"Transcriptional regulation of muscle fatty acid-binding protein.," Biochemical Journal 298, no.
3 (March 1994),
http://hdl.handle.net/10342/3246 (accessed
September 26, 2023).
AMA:
Carey, Julie O., Neufer, P. Darrell, Farrar, Roger P., Veerkamp, Jacques H., Dohm, G. Lynis.
Transcriptional regulation of muscle fatty acid-binding protein.. Biochemical Journal.
March 1994;
298(3):
613-617.
http://hdl.handle.net/10342/3246. Accessed
September 26, 2023.
Collections
Publisher
East Carolina University