Intramuscular Lipid Metabolism, Insulin Action and Obesity
Consitt, Leslie A.; Bell, Jill A.; Houmard, Joseph A.
With the increasing prevalence of obesity, research has focused on the molecular mechanism(s) linking obesity and skeletal muscle insulin resistance. Metabolic alterations within muscle, such as changes in the cellular location of fatty acid transporter proteins, decreased mitochondrial enzyme activity and defects in mitochondrial morphology, likely contribute to obesity and insulin resistance. These defects are thought to play a role in the reduced skeletal muscle fatty acid oxidation (FAO) and increased intramuscular lipid (IMCL) accumulation that is apparent with obesity and other insulin resistant states, such as type 2 diabetes. Intramuscular triacylglycerol (IMTG) does not appear to be a ubiquitous marker of insulin resistance, although specific IMCL intermediates such as long-chain fatty acyl-CoAs (LCFA-CoAs), ceramide and diacylglycerol (DAG) may inhibit insulin signal transduction. In this review, we will briefly summarize the defects in skeletal muscle lipid metabolism associated with obesity, and discuss proposed mechanisms by which these defects may contribute to insulin resistance. Originally published IUBMB Life, Vol. 6, No. 1, Jan 2009
Consitt, Leslie A., & Bell, Jill A., & Houmard, Joseph A.. (January 2009). Intramuscular Lipid Metabolism, Insulin Action and Obesity. IUBMB Life, (6:1), p.47-55. Retrieved from http://hdl.handle.net/10342/3252
Consitt, Leslie A., and Bell, Jill A., and Houmard, Joseph A.. "Intramuscular Lipid Metabolism, Insulin Action and Obesity". IUBMB Life. 6:1. (47-55.), January 2009. October 26, 2020. http://hdl.handle.net/10342/3252.
Consitt, Leslie A. and Bell, Jill A. and Houmard, Joseph A., "Intramuscular Lipid Metabolism, Insulin Action and Obesity," IUBMB Life 6, no. 1 (January 2009), http://hdl.handle.net/10342/3252 (accessed October 26, 2020).
Consitt, Leslie A., Bell, Jill A., Houmard, Joseph A.. Intramuscular Lipid Metabolism, Insulin Action and Obesity. IUBMB Life. January 2009; 6(1) 47-55. http://hdl.handle.net/10342/3252. Accessed October 26, 2020.
East Carolina University