Orphan Glutamate Receptor delta-1 Subunit Required for High-Frequency Hearing

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Author
Gao, Jiangang; Maison, Stephane F.; Wu, Xudong; Hirose, Keiko; Jones, Sherri M.; Bayazitov, Ildar; Tian, Yong; Mittleman, Guy; Matthews, Douglas B.; Zakharenko, Stanislav S.; Liberman, M. Charles; Zuo, Jian
Abstract
The function of the orphan glutamate receptor delta subunits (GluR 1 and GluR 2) remains unclear. GluR 2 is expressed exclusively in the Purkinje cells of the cerebellum, and GluR 1 is prominently expressed in inner ear hair cells and neurons of the hippocampus. We found that mice lacking the GluR 1 protein displayed significant cochlear threshold shifts for frequencies of >16 kHz. These deficits correlated with a substantial loss of type IV spiral ligament fibrocytes and a significant reduction of endolymphatic potential in high-frequency cochlear regions. Vulnerability to acoustic injury was significantly enhanced; however, the efferent innervation of hair cells and the classic efferent inhibition of outer hair cells were unaffected. Hippocampal and vestibular morphology and function were normal. Our findings show that the orphan GluR 1 plays an essential role in high-frequency hearing and ionic homeostasis in the basal cochlea, and the locus encoding GluR 1 represents a candidate gene for congenital or acquired high-frequency hearing loss in humans. Originally published Molecular and Cellular Biology, Vol. 27, No. 12, June 2007
URI
http://hdl.handle.net/10342/3292
Subject
 Orphan glutamate receptor; High-frequency hearing loss; Ionic homeostasis; Basal cochlea 
Date
2007-06
Citation:
APA:
Gao, Jiangang, & Maison, Stephane F., & Wu, Xudong, & Hirose, Keiko, & Jones, Sherri M., & Bayazitov, Ildar, & Tian, Yong, & Mittleman, Guy, & Matthews, Douglas B., & Zakharenko, Stanislav S., & Liberman, M. Charles, & Zuo, Jian. (June 2007). Orphan Glutamate Receptor delta-1 Subunit Required for High-Frequency Hearing. Molecular and Cellular Biology, 27(12), 4500- 4512. Retrieved from http://hdl.handle.net/10342/3292

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MLA:
Gao, Jiangang, and Maison, Stephane F., and Wu, Xudong, and Hirose, Keiko, and Jones, Sherri M., and Bayazitov, Ildar, and Tian, Yong, and Mittleman, Guy, and Matthews, Douglas B., and Zakharenko, Stanislav S., and Liberman, M. Charles, and Zuo, Jian. "Orphan Glutamate Receptor delta-1 Subunit Required for High-Frequency Hearing". Molecular and Cellular Biology. 27:12. (4500-4512), June 2007. September 22, 2023. http://hdl.handle.net/10342/3292.
Chicago:
Gao, Jiangang and Maison, Stephane F. and Wu, Xudong and Hirose, Keiko and Jones, Sherri M. and Bayazitov, Ildar and Tian, Yong and Mittleman, Guy and Matthews, Douglas B. and Zakharenko, Stanislav S. and Liberman, M. Charles and Zuo, Jian, "Orphan Glutamate Receptor delta-1 Subunit Required for High-Frequency Hearing," Molecular and Cellular Biology 27, no. 12 (June 2007), http://hdl.handle.net/10342/3292 (accessed September 22, 2023).
AMA:
Gao, Jiangang, Maison, Stephane F., Wu, Xudong, Hirose, Keiko, Jones, Sherri M., Bayazitov, Ildar, Tian, Yong, Mittleman, Guy, Matthews, Douglas B., Zakharenko, Stanislav S., Liberman, M. Charles, Zuo, Jian. Orphan Glutamate Receptor delta-1 Subunit Required for High-Frequency Hearing. Molecular and Cellular Biology. June 2007; 27(12): 4500-4512. http://hdl.handle.net/10342/3292. Accessed September 22, 2023.
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East Carolina University