Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover
Author
Kim, Jin-Sook; Bareiss, Sonja; Kim, Kyung Keun; Tatum, Rodney; Han, Jeong-Ran; Jin, Yun Hye; Kim, Hangun; Lu, Qun; Kim, Kwonseop
Abstract
Although delta-catenin/neural plakophilin-related armadillo protein (NPRAP) was reported to interact with presenilin-1 (PS-1), the effects of PS-1 on delta-catenin have not been established. In this study, we report that overexpression of PS-1 inhibits the delta-catenin-induced dendrite-like morphological changes in NIH 3T3 cells and promotes delta-catenin processing and turnover. The effects of PS-1 on endogenous delta-catenin processing were confirmed in hippocampal neurons overexpressing PS-1, as well as in the transgenic mice expressing the disease-causing mutant PS-1 (M146V). In addition, disease-causing mutant PS-1 (M146V and L286V) enhanced delta-catenin processing, whereas PS-1/gamma-secretase inhibitors could block the formation of processed forms of delta-catenin. Together, our findings suggest that PS-1 can affect delta-catenin-induced morphogenesis possibly through the regulation of its processing and stability. Originally published Biochem Biophys Res Commun, Vol. 351, No. 4, Dec 2006
Date
2006-12-29
Citation:
APA:
Kim, Jin-Sook, & Bareiss, Sonja, & Kim, Kyung Keun, & Tatum, Rodney, & Han, Jeong-Ran, & Jin, Yun Hye, & Kim, Hangun, & Lu, Qun, & Kim, Kwonseop. (December 2006).
Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover.
Biochemical and Biophysical Research Communications,
351(4),
903-
908. Retrieved from
http://hdl.handle.net/10342/3325
MLA:
Kim, Jin-Sook, and Bareiss, Sonja, and Kim, Kyung Keun, and Tatum, Rodney, and Han, Jeong-Ran, and Jin, Yun Hye, and Kim, Hangun, and Lu, Qun, and Kim, Kwonseop.
"Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover". Biochemical and Biophysical Research Communications.
351:4. (903-908),
December 2006.
May 31, 2023.
http://hdl.handle.net/10342/3325.
Chicago:
Kim, Jin-Sook and Bareiss, Sonja and Kim, Kyung Keun and Tatum, Rodney and Han, Jeong-Ran and Jin, Yun Hye and Kim, Hangun and Lu, Qun and Kim, Kwonseop,
"Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover," Biochemical and Biophysical Research Communications 351, no.
4 (December 2006),
http://hdl.handle.net/10342/3325 (accessed
May 31, 2023).
AMA:
Kim, Jin-Sook, Bareiss, Sonja, Kim, Kyung Keun, Tatum, Rodney, Han, Jeong-Ran, Jin, Yun Hye, Kim, Hangun, Lu, Qun, Kim, Kwonseop.
Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover. Biochemical and Biophysical Research Communications.
December 2006;
351(4):
903-908.
http://hdl.handle.net/10342/3325. Accessed
May 31, 2023.
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Publisher
East Carolina University