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    Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover

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    Author
    Kim, Jin-Sook; Bareiss, Sonja; Kim, Kyung Keun; Tatum, Rodney; Han, Jeong-Ran; Jin, Yun Hye; Kim, Hangun; Lu, Qun; Kim, Kwonseop
    Abstract
    Although delta-catenin/neural plakophilin-related armadillo protein (NPRAP) was reported to interact with presenilin-1 (PS-1), the effects of PS-1 on delta-catenin have not been established. In this study, we report that overexpression of PS-1 inhibits the delta-catenin-induced dendrite-like morphological changes in NIH 3T3 cells and promotes delta-catenin processing and turnover. The effects of PS-1 on endogenous delta-catenin processing were confirmed in hippocampal neurons overexpressing PS-1, as well as in the transgenic mice expressing the disease-causing mutant PS-1 (M146V). In addition, disease-causing mutant PS-1 (M146V and L286V) enhanced delta-catenin processing, whereas PS-1/gamma-secretase inhibitors could block the formation of processed forms of delta-catenin. Together, our findings suggest that PS-1 can affect delta-catenin-induced morphogenesis possibly through the regulation of its processing and stability. Originally published Biochem Biophys Res Commun, Vol. 351, No. 4, Dec 2006
    URI
    http://hdl.handle.net/10342/3325
    Subject
     Alzheimer's disease; [Delta]-catenin/NPRAP; Presenilin/gamma-secretase; δ-catenin/NPRAP 
    Date
    2006-12-29
    Citation:
    APA:
    Kim, Jin-Sook, & Bareiss, Sonja, & Kim, Kyung Keun, & Tatum, Rodney, & Han, Jeong-Ran, & Jin, Yun Hye, & Kim, Hangun, & Lu, Qun, & Kim, Kwonseop. (December 2006). Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover. , (. Retrieved from http://hdl.handle.net/10342/3325

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Kim, Jin-Sook, and Bareiss, Sonja, and Kim, Kyung Keun, and Tatum, Rodney, and Han, Jeong-Ran, and Jin, Yun Hye, and Kim, Hangun, and Lu, Qun, and Kim, Kwonseop. "Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover". . . (.), December 2006. July 06, 2022. http://hdl.handle.net/10342/3325.
    Chicago:
    Kim, Jin-Sook and Bareiss, Sonja and Kim, Kyung Keun and Tatum, Rodney and Han, Jeong-Ran and Jin, Yun Hye and Kim, Hangun and Lu, Qun and Kim, Kwonseop, "Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover,"  , no. (December 2006), http://hdl.handle.net/10342/3325 (accessed July 06, 2022).
    AMA:
    Kim, Jin-Sook, Bareiss, Sonja, Kim, Kyung Keun, Tatum, Rodney, Han, Jeong-Ran, Jin, Yun Hye, Kim, Hangun, Lu, Qun, Kim, Kwonseop. Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover. . December 2006; () . http://hdl.handle.net/10342/3325. Accessed July 06, 2022.
    Collections
    • Pharmacology and Toxicology
    Publisher
    East Carolina University

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