Cranial Ultrasound Lesions in the NICU Predict Cerebral Palsy at Age 2 Years in Children Born at Extremely Low Gestational Age
Author
Kuban, Karl C. K.; Allred, Elizabeth N.; O'Shea, T. Michael; Paneth, Nigel; Pagano, Marcello; Dammann, Olaf; Leviton, Alan; Plessis, Adre Du; Westra, Sjirk J.; Miller, Cindy R.; Bassan, Haim; Krishnamoorthy, Kalpathy; Junewick, Joseph; Olomu, Nicholas; Romano, Elaine; Seibert, Joanna; Engelke, Stephen C.; Karna, Padmani; Batton, Daniel; O'Connor, Sunila E.; Keller, Cecelia E.
Abstract
Our prospective cohort study of extremely low gestational age newborns evaluated the association of neonatal head ultrasound abnormalities with cerebral palsy at age 2 years. Cranial ultrasounds in 1053 infants were read with respect to intraventricular hemorrhage, ventriculomegaly, and echolucency, by multiple sonologists. Standardized neurological examinations classified cerebral palsy, and functional impairment was assessed. Forty-four percent with ventriculomegaly and 52% with echolucency developed cerebral palsy. Compared with no ultrasound abnormalities, children with echolucency were 24 times more likely to have quadriparesis and 29 times more likely to have hemiparesis. Children with ventriculomegaly were 17 times more likely to have quadriparesis or hemiparesis. Forty-three percent of children with cerebral palsy had normal head ultrasound. Focal white matter damage (echolucency) and diffuse damage (late ventriculomegaly) are associated with a high probability of cerebral palsy, especially quadriparesis. Nearly half the cerebral palsy identified at 2 years is not preceded by a neonatal brain ultrasound abnormality. Originally published Journal of Child Neurology, Vol. 24, No. 1, Jan 2009
Date
2009-01
Citation:
APA:
Kuban, Karl C. K., & Allred, Elizabeth N., & O'Shea, T. Michael, & Paneth, Nigel, & Pagano, Marcello, & Dammann, Olaf, & Leviton, Alan, & Plessis, Adre Du, & Westra, Sjirk J., & Miller, Cindy R., & Bassan, Haim, & Krishnamoorthy, Kalpathy, & Junewick, Joseph, & Olomu, Nicholas, & Romano, Elaine, & Seibert, Joanna, & Engelke, Stephen C., & Karna, Padmani, & Batton, Daniel, & O'Connor, Sunila E., & Keller, Cecelia E.. (January 2009).
Cranial Ultrasound Lesions in the NICU Predict Cerebral Palsy at Age 2 Years in Children Born at Extremely Low Gestational Age.
Journal of Child Neurology,
24(1),
63-
72. Retrieved from
http://hdl.handle.net/10342/3330
MLA:
Kuban, Karl C. K., and Allred, Elizabeth N., and O'Shea, T. Michael, and Paneth, Nigel, and Pagano, Marcello, and Dammann, Olaf, and Leviton, Alan, and Plessis, Adre Du, and Westra, Sjirk J., and Miller, Cindy R., and Bassan, Haim, and Krishnamoorthy, Kalpathy, and Junewick, Joseph, and Olomu, Nicholas, and Romano, Elaine, and Seibert, Joanna, and Engelke, Stephen C., and Karna, Padmani, and Batton, Daniel, and O'Connor, Sunila E., and Keller, Cecelia E..
"Cranial Ultrasound Lesions in the NICU Predict Cerebral Palsy at Age 2 Years in Children Born at Extremely Low Gestational Age". Journal of Child Neurology.
24:1. (63-72),
January 2009.
October 03, 2023.
http://hdl.handle.net/10342/3330.
Chicago:
Kuban, Karl C. K. and Allred, Elizabeth N. and O'Shea, T. Michael and Paneth, Nigel and Pagano, Marcello and Dammann, Olaf and Leviton, Alan and Plessis, Adre Du and Westra, Sjirk J. and Miller, Cindy R. and Bassan, Haim and Krishnamoorthy, Kalpathy and Junewick, Joseph and Olomu, Nicholas and Romano, Elaine and Seibert, Joanna and Engelke, Stephen C. and Karna, Padmani and Batton, Daniel and O'Connor, Sunila E. and Keller, Cecelia E.,
"Cranial Ultrasound Lesions in the NICU Predict Cerebral Palsy at Age 2 Years in Children Born at Extremely Low Gestational Age," Journal of Child Neurology 24, no.
1 (January 2009),
http://hdl.handle.net/10342/3330 (accessed
October 03, 2023).
AMA:
Kuban, Karl C. K., Allred, Elizabeth N., O'Shea, T. Michael, Paneth, Nigel, Pagano, Marcello, Dammann, Olaf, Leviton, Alan, Plessis, Adre Du, Westra, Sjirk J., Miller, Cindy R., Bassan, Haim, Krishnamoorthy, Kalpathy, Junewick, Joseph, Olomu, Nicholas, Romano, Elaine, Seibert, Joanna, Engelke, Stephen C., Karna, Padmani, Batton, Daniel, O'Connor, Sunila E., Keller, Cecelia E..
Cranial Ultrasound Lesions in the NICU Predict Cerebral Palsy at Age 2 Years in Children Born at Extremely Low Gestational Age. Journal of Child Neurology.
January 2009;
24(1):
63-72.
http://hdl.handle.net/10342/3330. Accessed
October 03, 2023.
Collections
Publisher
East Carolina University