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    Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein

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    Author
    Landry, Sebastien; Halin, Marilene; Vargas, Amandine; Lemasson, Isabelle; Mesnard, Jean-Michel; Barbeau, Benoit
    Abstract
    Several studies have recently demonstrated the existence of human T-cell leukemia virus type 1 (HTLV-1) antisense transcripts, which allow the synthesis of the newly described HBZ protein. Although previous reports have been aimed at understanding the potential role of the HBZ protein in HTLV-1 pathogenesis, little is known as to how this viral gene is regulated. Here, using our K30-3 asLuc reporter construct, we show that the viral Tax protein upregulates antisense transcription through its action on the TRE sequences located in the 3 long terminal repeat. Generation of stable clones in 293T cells demonstrated that Tax-induced HBZ expression is importantly influenced by the integration site in the host genome. The cellular DNA context could thus affect the level of HBZ mRNA expression in infected cells. Originally published Journal of Virology, Vol. 83, No. 4, Feb 2009
    URI
    http://hdl.handle.net/10342/3334
    Subject
     HTLV-1; HBZ protein; Antisense transcripts 
    Date
    2009-02
    Citation:
    APA:
    Landry, Sebastien, & Halin, Marilene, & Vargas, Amandine, & Lemasson, Isabelle, & Mesnard, Jean-Michel, & Barbeau, Benoit. (February 2009). Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein. Journal of Virology, 83(4), 2048- 2054. Retrieved from http://hdl.handle.net/10342/3334

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Landry, Sebastien, and Halin, Marilene, and Vargas, Amandine, and Lemasson, Isabelle, and Mesnard, Jean-Michel, and Barbeau, Benoit. "Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein". Journal of Virology. 83:4. (2048-2054), February 2009. December 01, 2023. http://hdl.handle.net/10342/3334.
    Chicago:
    Landry, Sebastien and Halin, Marilene and Vargas, Amandine and Lemasson, Isabelle and Mesnard, Jean-Michel and Barbeau, Benoit, "Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein," Journal of Virology 83, no. 4 (February 2009), http://hdl.handle.net/10342/3334 (accessed December 01, 2023).
    AMA:
    Landry, Sebastien, Halin, Marilene, Vargas, Amandine, Lemasson, Isabelle, Mesnard, Jean-Michel, Barbeau, Benoit. Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein. Journal of Virology. February 2009; 83(4): 2048-2054. http://hdl.handle.net/10342/3334. Accessed December 01, 2023.
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    • Microbiology and Immunology
    Publisher
    East Carolina University

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