• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Division of Health Sciences
    • Brody School of Medicine
    • Anatomy and Cell Biology
    • View Item
    •   ScholarShip Home
    • Division of Health Sciences
    • Brody School of Medicine
    • Anatomy and Cell Biology
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Evidence for the presence of A1 adenosine receptors in the aorta of spontaneously hypertensive rats

    Thumbnail
    View/ Open
    Evidence presence adenosine receptors.pdf (175.5Kb)

    Show full item record
    Author
    Fahim, Mohammed; Mustafa, Syed Jamal
    Abstract
    1 Isolated aortic rings (endothelium-intact and -denuded) from spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats were used in this study to examine the vasoactive e ects of various adenosine analogues. 2 In phenylephrine contracted aortic rings, concentration-response curves were constructed by cumulative additions (10711 ±1075 M) of (2S)-N6-[2-endo-Norbornyl] adenosine (ENBA), N6- cyclopentyladenosine (CPA), R-N6-(2-phenylisopropyl) adenosine (R-PIA), 2-p-(-2-carboxyethyl) phenethylamino-5'-N-thylcarboxamido adenosine (CGS-21680). 3 A non-speci®c adenosine receptor agonist 2-chloroadenosine (CAD) resulted in biphasic response with a small contraction at lower concentrations (1079 ±1078 M) followed by a signi®cant relaxation at higher concentration in endothelium-intact SHR tissues, suggesting presence of both A1 and A2 adenosine receptors in SHR aorta. However, only relaxation was observed in WKY. 4 Contractile response in SHR had the following rank order of potency: ENBA4CPA4R- PIA4CAD. The relaxation response in SHR and WKY had the following rank order of potency: CGS 216804CAD4R-PIA4CPA4ENBA. 5 Removal of endothelium abolished the adenosine analogue induced contractions in SHR aorta and attenuated the vasorelaxation responses in the WKY and SHR. 6 The contractile response in SHR was abolished by A1 adenosine receptor antagonist N6- endonorbornan-2-yl-9-methyladenine (N-0861). A2 adenosine receptor antagonist, 3,7-dimethyl-1-proparglyxanthine (DMPX) did not a ect the contraction response of adenosine analogues. 7 Endothelium-dependent contractions elicited by A1 receptor agonists were blocked by indomethacin and by free radical scavengers. 8 These data suggest that the contractile response to adenosine analogues in SHR aorta is probably mediated by free radicals which are generated through the increased cyclo-oxygenase activity occurring in the vascular endothelium of SHR but not the WKY rats. British Journal of Pharmacology (2001) 134, 1760 ± 1766. Originally published British Journal of Pharmacology, Vol. 134, No. 8, Dec 2001
    URI
    http://hdl.handle.net/10342/3441
    Subject
     A1 adenosine receptor; A2 adenosine receptor; Vascular endothelium; Vascular smooth muscle; Indomethacin; Free radicals 
    Date
    2001-12
    Citation:
    APA:
    Fahim, Mohammed, & Mustafa, Syed Jamal. (December 2001). Evidence for the presence of A1 adenosine receptors in the aorta of spontaneously hypertensive rats. British Journal of Pharmacology, 134(8), 1760- 1766. Retrieved from http://hdl.handle.net/10342/3441

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Fahim, Mohammed, and Mustafa, Syed Jamal. "Evidence for the presence of A1 adenosine receptors in the aorta of spontaneously hypertensive rats". British Journal of Pharmacology. 134:8. (1760-1766), December 2001. May 29, 2023. http://hdl.handle.net/10342/3441.
    Chicago:
    Fahim, Mohammed and Mustafa, Syed Jamal, "Evidence for the presence of A1 adenosine receptors in the aorta of spontaneously hypertensive rats," British Journal of Pharmacology 134, no. 8 (December 2001), http://hdl.handle.net/10342/3441 (accessed May 29, 2023).
    AMA:
    Fahim, Mohammed, Mustafa, Syed Jamal. Evidence for the presence of A1 adenosine receptors in the aorta of spontaneously hypertensive rats. British Journal of Pharmacology. December 2001; 134(8): 1760-1766. http://hdl.handle.net/10342/3441. Accessed May 29, 2023.
    Collections
    • Anatomy and Cell Biology
    Publisher
    East Carolina University

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback