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    REGULATION OF LIPOLYSIS BY [BETA]-ADRENERGIC ACTIVATION AND EXERCISE IN OBESE AFRICAN-AMERICAN AND CAUCASIAN WOMEN

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    Author
    Raymer, Dustin K.
    Abstract
    African-American women (AAW) are twice as likely to be obese as Caucasian women (CW); however, previous in-vitro studies have shown that AAW have higher densities of beta-adrenergic receptors (B-AR) in the subcutaneous (SC) adipose tissue and an increased lipolytic response to B-AR stimulation when compared to CW. There are no in-vivo studies to help resolve this apparent contradiction between in-vitro lipolytic response and the incidence of obesity. The purpose of this study is therefore to determine if AAW, as compared to CW, have a larger lipolytic response to pharmacological (isoproterenol) and physiological (exercise) stimulation. Methods: 33 obese women (16 AAW; 17 CW) participated in the microdialysis (MD) study. MD consisted of two probes placed in SC abdominal adipose tissue and perfused with either isoproterenol (ISO) or a control solution. Dialysate glycerol (index of lipolysis) was measured from probes at rest and, from the control probe, during exercise. Results: Dialysate glycerol increased 384.9% in AAW and 191.2% in CW in response to ISO (p=0.046 AAW vs CW). Dialysate glycerol increased 66 [mu]mol/L in AAW and 84 [mu]mol/L in CW in response to exercise (p=0.94 AAW vs CW). Conclusion: AAW have a higher lipolytic response to pharmacological B-AR stimulation, but have a similar lipolytic response to exercise, as compared to CW. These findings suggest that lipolytic response to B-AR stimulation and exercise are likely not contributing factors to the higher incidence of obesity in AAW as compared to CW.
    URI
    http://hdl.handle.net/10342/3880
    Subject
     Health sciences; Demography; African Americans; Beta adrenergic; Exercise; Lipolysis; Racial 
    Date
    2012
    Citation:
    APA:
    Raymer, Dustin K.. (January 2012). REGULATION OF LIPOLYSIS BY [BETA]-ADRENERGIC ACTIVATION AND EXERCISE IN OBESE AFRICAN-AMERICAN AND CAUCASIAN WOMEN (Master's Thesis, East Carolina University). Retrieved from the Scholarship. (http://hdl.handle.net/10342/3880.)

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    MLA:
    Raymer, Dustin K.. REGULATION OF LIPOLYSIS BY [BETA]-ADRENERGIC ACTIVATION AND EXERCISE IN OBESE AFRICAN-AMERICAN AND CAUCASIAN WOMEN. Master's Thesis. East Carolina University, January 2012. The Scholarship. http://hdl.handle.net/10342/3880. April 19, 2021.
    Chicago:
    Raymer, Dustin K., “REGULATION OF LIPOLYSIS BY [BETA]-ADRENERGIC ACTIVATION AND EXERCISE IN OBESE AFRICAN-AMERICAN AND CAUCASIAN WOMEN” (Master's Thesis., East Carolina University, January 2012).
    AMA:
    Raymer, Dustin K.. REGULATION OF LIPOLYSIS BY [BETA]-ADRENERGIC ACTIVATION AND EXERCISE IN OBESE AFRICAN-AMERICAN AND CAUCASIAN WOMEN [Master's Thesis]. Greenville, NC: East Carolina University; January 2012.
    Collections
    • Kinesiology
    • Master's Theses
    Publisher
    East Carolina University

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