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Now showing items 11-20 of 22
NOVEL BIOLOGICS PROMOTE STABLE EXPANSION OF REGULATORY CD25HIGH FOXP3+ T LYMPHOCYTES AS A MEANS FOR AN ADOPTIVE CELL-BASED IMMUNOTHERAPY
(East Carolina University, 2021-06-18)
Autoimmune disease arises when a breakdown in immunological self-tolerance causes self-reactive tissue destruction. In Multiple Sclerosis (MS), myelin reactive CD4+ T cells initiate an immune attack on the myelin sheath ...
DELINEATING THE ROLE OF SOLUBLE CD25 AS AN IMMUNOREGULATORY MOLECULE THAT PROMOTES A LOW-ZONE IL-2 SIGNALING ENVIRONMENT FAVORABLE FOR THE SELECTION OF CD25HIGH FOXP3HIGH T CELLS
(East Carolina University, 2021-07-22)
Autoimmune diseases develop due to the breakdown of tolerogenic mechanisms that normally maintain immune homeostasis. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are critical in the maintenance of tolerance and the ...
The respective roles of BfmRS and PmrA in stress responses and antibiotic resistance in Acinetobacter baumannii
(East Carolina University, 2021-09-22)
The Gram-negative bacterium Acinetobacter baumannii is considered one of the most serious nosocomial pathogens worldwide. Predominantly responsible for ventilator-associated pneumonia, this insidious pathogen typically ...