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Role of the Iron Storage Ferritins Dps and DpsL during the Prolonged Oxidative Stress Response of Bacteroides fragilis
(East Carolina University, 2015-12-02)
Bacteroides fragilis is a Gram negative anaerobe and member of the human intestinal tract microbiome. B. fragilis serves many beneficial roles within the intestinal tract; however, its translocation to the peritoneal cavity ...
Experimental autoimmune encephalomyelitis as a model of Multiple Sclerosis : pathogenesis of atypical disease and tolerance induction in chronic progressive disease
(East Carolina University, 2015)
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin characterized by focal inflammatory lesions together with demyelinating plaques in the ...
Selection and stabilization of CD25high FOXP3+ regulatory T cells in vitro as a basis for adoptive antigen-specific immunotherapy
(East Carolina University, 2017-08-16)
Autoimmune disease affects an estimated 50 million people in the United States. Autoimmune disease arises when immune tolerance is abrogated and host immune cells mount an attack against self-tissues. For example, in ...
Lyme Disease Pathogenesis
(2021)
Attenuated viruses and method of making the same
(1996-04-18)
Disclosed are attenuated viruses, not naturally occurring, that contain one or more additional methylation sites in the genome of the virus compared to the corresponding wild-type virus. Preferably, the methylation sites ...