Acute Effects of Fine Particulate Air Pollution on Cardiac Arrhythmia: The APACR Study
He, Fan; Shaffer, Michele L.; Rodriguez-Colon, Sol; Yanosky, Jeff D.; Bixler, Edward; Cascio, Wayne E.; Liao, Duanping
Background: The mechanisms underlying the relationship between particulate matter (PM) air pollution and cardiac disease are not fully understood. Objectives: We examined the effects and time course of exposure to fine PM [aerodynamic diameter ≤ 2.5 μm (PM2.5)] on cardiac arrhythmia in 105 middle-age community-dwelling healthy nonsmokers in central Pennsylvania. Methods: The 24-hr beat-to-beat electrocardiography data were obtained using a high-resolution Holter system. After visually identifying and removing artifacts, we summarized the total number of premature ventricular contractions (PVCs) and premature atrial contractions (PACs) for each 30-min segment. A personal PM2.5 nephelometer was used to measure individual-level real-time PM2.5 exposures for 24 hr. We averaged these data to obtain 30-min average time–specific PM2.5 exposures. Distributed lag models under the framework of negative binomial regression and generalized estimating equations were used to estimate the rate ratio between 10-μg/m3 increases in average PM2.5 over 30-min intervals and ectopy counts. Results: The mean ± SD age of participants was 56 ± 8 years, with 40% male and 73% non-Hispanic white. The 30-min mean ± SD for PM2.5 exposure was 13 ± 22 μg/m3, and PAC and PVC counts were 0.92 ± 4.94 and 1.22 ± 7.18. Increases of 10 μg/m3 in average PM2.5 concentrations during the same 30 min or the previous 30 min were associated with 8% and 3% increases in average PVC counts, respectively. PM2.5 was not significantly associated with PAC count. Conclusion: PM2.5 exposure within approximately 60 min was associated with increased PVC counts in healthy individuals.
He, Fan, & Shaffer, Michele L., & Rodriguez-Colon, Sol, & Yanosky, Jeff D., & Bixler, Edward, & Cascio, Wayne E., & Liao, Duanping. (March 2011). Acute Effects of Fine Particulate Air Pollution on Cardiac Arrhythmia: The APACR Study. Environmental Health Perspectives, (119:7), p.927-932. Retrieved from http://hdl.handle.net/10342/5430
He, Fan, and Shaffer, Michele L., and Rodriguez-Colon, Sol, and Yanosky, Jeff D., and Bixler, Edward, and Cascio, Wayne E., and Liao, Duanping. "Acute Effects of Fine Particulate Air Pollution on Cardiac Arrhythmia: The APACR Study". Environmental Health Perspectives. 119:7. (927-932.), March 2011. April 02, 2020. http://hdl.handle.net/10342/5430.
He, Fan and Shaffer, Michele L. and Rodriguez-Colon, Sol and Yanosky, Jeff D. and Bixler, Edward and Cascio, Wayne E. and Liao, Duanping, "Acute Effects of Fine Particulate Air Pollution on Cardiac Arrhythmia: The APACR Study," Environmental Health Perspectives 119, no. 7 (March 2011), http://hdl.handle.net/10342/5430 (accessed April 02, 2020).
He, Fan, Shaffer, Michele L., Rodriguez-Colon, Sol, Yanosky, Jeff D., Bixler, Edward, Cascio, Wayne E., Liao, Duanping. Acute Effects of Fine Particulate Air Pollution on Cardiac Arrhythmia: The APACR Study. Environmental Health Perspectives. March 2011; 119(7) 927-932. http://hdl.handle.net/10342/5430. Accessed April 02, 2020.