Author | He, Fan | |
Author | Shaffer, Michele L. | |
Author | Rodriguez-Colon, Sol | |
Author | Yanosky, Jeff D. | |
Author | Bixler, Edward O. | |
Author | Cascio, Wayne E. | |
Author | Liao, Duanping | |
Date Accessioned | 2016-05-31T17:19:41Z | |
Date Available | 2016-05-31T17:19:41Z | |
Date of Issue | 2011-03 | |
Identifier (Citation) | Environmental Health Perspectives; 119:7 p. 927-932 | en_US |
ISSN | 0091-6765 | |
Identifier (URI) | http://hdl.handle.net/10342/5430 | |
Description | Background: The mechanisms underlying the relationship between particulate matter (PM) air pollution and cardiac disease are not fully understood.
Objectives: We examined the effects and time course of exposure to fine PM [aerodynamic diameter ≤ 2.5 μm (PM2.5)] on cardiac arrhythmia in 105 middle-age community-dwelling healthy nonsmokers in central Pennsylvania.
Methods: The 24-hr beat-to-beat electrocardiography data were obtained using a high-resolution Holter system. After visually identifying and removing artifacts, we summarized the total number of premature ventricular contractions (PVCs) and premature atrial contractions (PACs) for each 30-min segment. A personal PM2.5 nephelometer was used to measure individual-level real-time PM2.5 exposures for 24 hr. We averaged these data to obtain 30-min average time–specific PM2.5 exposures. Distributed lag models under the framework of negative binomial regression and generalized estimating equations were used to estimate the rate ratio between 10-μg/m3 increases in average PM2.5 over 30-min intervals and ectopy counts.
Results: The mean ± SD age of participants was 56 ± 8 years, with 40% male and 73% non-Hispanic white. The 30-min mean ± SD for PM2.5 exposure was 13 ± 22 μg/m3, and PAC and PVC counts were 0.92 ± 4.94 and 1.22 ± 7.18. Increases of 10 μg/m3 in average PM2.5 concentrations during the same 30 min or the previous 30 min were associated with 8% and 3% increases in average PVC counts, respectively. PM2.5 was not significantly associated with PAC count.
Conclusion: PM2.5 exposure within approximately 60 min was associated with increased PVC counts in healthy individuals. | en_US |
Related URI | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222979/ | en_US |
Subject | cardiac arrhythmia | en_US |
Subject | cardiovascular disease | en_US |
Subject | PAC | en_US |
Subject | particulate matter | en_US |
Subject | PVC | en_US |
Title | Acute Effects of Fine Particulate Air Pollution on Cardiac Arrhythmia: The APACR Study | en_US |
Type | Article | en_US |
Identifier (PMID) | pmc3222979 | en_US |
Identifier (DOI) | 10.1289/ehp.1002640 | |
Journal Name | Environmental Health Perspectives | en_US |
Journal Volume | 119 | en_US |
Journal Issue | 7 | en_US |
Article Pages | 927-932 | en_US |