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Targeting aberrant signaling in the EGFR1/HER2/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway : Novel therapeutic interventions in breast cancer
(East Carolina University, 2015)
Breast cancer is attributed to being the second most deadly cancer in American women. Approximately 1 in 8 women will be diagnosed with breast cancer during her lifetime, and prognosis is dependent upon the genetic make-up ...
Paving the Way : A Biopsychosocial Survey Study of Young Adults Diagnosed with Heart Failure and Identification of Key Intervention Priorities
(East Carolina University, 2014)
Introduction: Rates of heart failure have been increasingly noticed in individuals between 20 and 50 years of age, especially in Eastern North Carolina. Little is known about this subset of patients with heart failure. The ...
Shedding Light on Dark Truths : The Interpretation of African American History at Tryon Palace in New Bern, NC
(East Carolina University, 2014)
Tryon Palace was home to the first royal governors of North Carolina. Today, the site is one of the most visited historic sites in the state. But what stories are visitors hearing? The historic homes and buildings at the ...
Physiological Studies of Alkaliphilic Anaerobic Organotrophs in a Serpentinizing Subsurface Habitat
(East Carolina University, 2014)
Microbial habitats in serpentinizing ultramafic rocks represent one of the largest, yet least understood portions of the biosphere, with potentially major consequences for global biogeochemical cycles. Serpentinization is ...
The Role of Transcription Factors Snail and Slug in Cardiac Myofibroblasts
(East Carolina University, 2014)
CCardiac fibrosis is a major facet contributing to cardiac dysfunction following a myocardial infarction. Persistent and excessive collagen deposition via cardiac myofibroblasts is the hallmark of cardiac fibrosis. Cardiac ...
Stratigraphy and petroleum geology of the Alexander silstone in Doddridge and Ritchie Counties, West Virginia
(East Carolina University, 2014)
The Upper Devonian Alexander siltstone is an informally named drillers' unit that occurs throughout the eastern half of the gas-producing portion of the Appalachian basin. The Alexander is primarily a gas-producing unit ...
Urban Water Availability and Potential Future Stressors : A Case Study of Raleigh-Durham, North Carolina
(East Carolina University, 2014)
The line that once existed between geographic regions that are considered "water poor" and "water rich" is now being blurred. Water managers in "water rich" regions, such as the Southeastern United States, are starting to ...
Physiological and Phylogenetic Studies of the Biogeography of Alkaliphilic Heterotrophic Bacteria from Serpentinizing Habitats
(East Carolina University, 2014)
Serpentinization occurs when ultramafic rocks containing the mineral olivine react with water to produce highly reducing conditions, which are commonly coincident with high concentrations of hydrogen. Hydrogen provides ...
Dodge, Duck, Dip, Dive & Dependence: Using Dodgeball to Explore Frequency Dependent Selection
(2016-09)
The term frequency dependence describes scenarios in which the likelihood
of an event occurring is strongly tied to how common a particular trait is.
Understanding frequency dependence is key to understanding ...
Clogging information flow in ALS
(2014-09-05)
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating neurodegenerative disorder that causes a progressive loss of motor neurons, leading to paralysis and death typically within 2 to 5 ...