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    Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach

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    Author
    Shahzad, K; Fatima, A; Cadeiras, M; Wisniewski, N; Bondar, G; Cheng, R; Reed, E; Deng, MC
    Abstract
    In the post-genome era, high throughput gene expression profiling has been successfully used to develop genomic biomarker panels (GBP) that can be integrated into clinical decision making. The development of GBPs in the context of personalized medicine is a scientifically challenging and resource-intense process. It needs to be accomplished in a systematic phased approach to address biological variation related to a clinical phenotype (e.g. disease etiology, gender, etc.) and minimize technical variation (noise). Here we present the methodological aspects of GBP development based on the experience of the Cardiac Allograft Rejection Gene Expression Observation (CARGO) study, a study that lead to the development of a molecular classifier for rejection screening in heart transplant patients.
    URI
    http://hdl.handle.net/10342/5544
    Subject
     Post-genome era; biomarker panels; gene expression profiling; genomics; heart transplantation; molecular classifier; multiorgan dysfunction; personalized medicine 
    Date
    2012-06
    Citation:
    APA:
    Shahzad, K, & Fatima, A, & Cadeiras, M, & Wisniewski, N, & Bondar, G, & Cheng, R, & Reed, E, & Deng, MC. (June 2012). Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach. Current Genomics, (13:4), p.334-341. Retrieved from http://hdl.handle.net/10342/5544

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Shahzad, K, and Fatima, A, and Cadeiras, M, and Wisniewski, N, and Bondar, G, and Cheng, R, and Reed, E, and Deng, MC. "Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach". Current Genomics. 13:4. (334-341.), June 2012. April 14, 2021. http://hdl.handle.net/10342/5544.
    Chicago:
    Shahzad, K and Fatima, A and Cadeiras, M and Wisniewski, N and Bondar, G and Cheng, R and Reed, E and Deng, MC, "Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach," Current Genomics 13, no. 4 (June 2012), http://hdl.handle.net/10342/5544 (accessed April 14, 2021).
    AMA:
    Shahzad, K, Fatima, A, Cadeiras, M, Wisniewski, N, Bondar, G, Cheng, R, Reed, E, Deng, MC. Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach. Current Genomics. June 2012; 13(4) 334-341. http://hdl.handle.net/10342/5544. Accessed April 14, 2021.
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