Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach

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CG-13-334.PMC3394121.pdf (826.43 KB)

Date

2012-06

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Authors

Shahzad, K
Fatima, A
Cadeiras, Martin
Wisniewski, N
Bondar, Galyna
Cheng, R
Reed, E
Deng, Mario C.

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Abstract

In the post-genome era, high throughput gene expression profiling has been successfully used to develop genomic biomarker panels (GBP) that can be integrated into clinical decision making. The development of GBPs in the context of personalized medicine is a scientifically challenging and resource-intense process. It needs to be accomplished in a systematic phased approach to address biological variation related to a clinical phenotype (e.g. disease etiology, gender, etc.) and minimize technical variation (noise). Here we present the methodological aspects of GBP development based on the experience of the Cardiac Allograft Rejection Gene Expression Observation (CARGO) study, a study that lead to the development of a molecular classifier for rejection screening in heart transplant patients.

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Keywords

Post-genome era , biomarker panels , gene expression profiling , genomics , heart transplantation , molecular classifier , multiorgan dysfunction , personalized medicine

Citation

Current Genomics; 13:4 p. 334-341

DOI

10.2174/138920212800793339

URI

http://hdl.handle.net/10342/5544

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Internal Medicine