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    Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling

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    Author
    Grammatikos, Alexandros P.; Ghosh, Debjani; Devlin, Amy; Kyttaris, Vasileios C.; Tsokos, George C.
    Abstract
    Engagement of the CD3/T cell receptor complex in systemic lupus erythematosus (SLE) T cells involves Syk rather than the zeta-associated protein. Because Syk is being considered as a therapeutic target we asked whether Syk is central to the multiple aberrantly modulated molecules in SLE T cells. Using a gene expression array, we demonstrate that forced expression of Syk in normal T cells reproduces most of the aberrantly expressed molecules whereas silencing of Syk in SLE T cells normalizes the expression of most abnormally expressed molecules. Protein along with gene expression modulation for select molecules was confirmed. Specifically, levels of cytokine IL-21, cell surface receptor CD44, and intracellular molecules PP2A and OAS2 increased following Syk overexpression in normal T cells and decreased after Syk silencing in SLE T cells. Our results demonstrate that levels of Syk affect the expression of a number of enzymes, cytokines and receptors that play a key role in the development of disease pathogenesis in SLE and provide support for therapeutic targeting in SLE patients.
    URI
    http://hdl.handle.net/10342/5577
    Subject
     T cells; Blood donors; Flow cytometry; Cytokines; Cytokines 
    Date
    2013
    Citation:
    APA:
    Grammatikos, Alexandros P., & Ghosh, Debjani, & Devlin, Amy, & Kyttaris, Vasileios C., & Tsokos, George C.. (January 2013). Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling. PLoS ONE, (8:8), p.1-9. Retrieved from http://hdl.handle.net/10342/5577

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    MLA:
    Grammatikos, Alexandros P., and Ghosh, Debjani, and Devlin, Amy, and Kyttaris, Vasileios C., and Tsokos, George C.. "Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling". PLoS ONE. 8:8. (1-9.), January 2013. March 06, 2021. http://hdl.handle.net/10342/5577.
    Chicago:
    Grammatikos, Alexandros P. and Ghosh, Debjani and Devlin, Amy and Kyttaris, Vasileios C. and Tsokos, George C., "Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling," PLoS ONE 8, no. 8 (January 2013), http://hdl.handle.net/10342/5577 (accessed March 06, 2021).
    AMA:
    Grammatikos, Alexandros P., Ghosh, Debjani, Devlin, Amy, Kyttaris, Vasileios C., Tsokos, George C.. Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling. PLoS ONE. January 2013; 8(8) 1-9. http://hdl.handle.net/10342/5577. Accessed March 06, 2021.
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