Browsing Biology by Title
Now showing items 98-117 of 1310
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Analyses of domains and domain fusions in human proto-oncogenes
(East Carolina University, 2009-03-17)Background: Understanding the constituent domains of oncogenes, their origins and their fusions may shed new light about the initiation and the development of cancers. Results: We have developed a computational pipeline ... -
Analyses of the oligopeptide transporter gene family in poplar and grape
(2011)Background Oligopeptide transporters (OPTs) are a group of membrane-localized proteins that have a broad range of substrate transport capabilities and that are thought to contribute to many biological processes. The OPT ... -
Analysis of a 41-year data set : Environmental influences on the fish assemblages of Albemarle Sound, North Carolina
(East Carolina University, 2014)North Carolina both historically and currently maintains one of the most productive fishery resource basins in the nation. However, fish stocks are spatially and temporally variable in abundance and distribution in estuarine ... -
Analysis of Complex DNA Damage Associated with Tumor Growth
(East Carolina University, 2012)The innate response of a fully functioning immune system's ability to recognize and react to the growth of a tumor by releasing reactive oxygen species (ROS) may lead to chronic inflammation in many cases. This chronic ... -
Analysis of Myopodin in Hela Cervical Carcinoma Cells
(East Carolina University, 2014)Synaptopodin-2 is a proline-rich, actin-binding protein that exists in many isoforms. Due to its large proline content, synaptopodin-2 exists in a naturally unfolded state and possesses the characteristics of a hub protein. ... -
Analysis of scn5Laa and scn5Lab Gene Function in Danio rerio (Zebrafish) Heart Development through TALENs/CRISPR-CAS9-mediated Gene Knockout
(East Carolina University, 2015)Research in our laboratory is focused on understanding the molecular developmental genetic effects of crude oil exposure on vertebrate embryogenesis. Our research has demonstrated that exposure of zebrafish embryos to ... -
Analysis of the hex regulon in Pseudomonas aeruginosa
(East Carolina University, 2012)Pseudomonas aeruginosa is an opportunistic pathogen whose defense mechanisms include biofilm production through carbohydrate metabolism. The activity of the enzymes in the hex regulon are required for catabolism of glucose ... -
Analysis of the Maize dicer-like1 Mutant, fuzzy tassel, Implicates MicroRNAs in Anther Maturation and Dehiscence
(2016-01-08)Sexual reproduction in plants requires development of haploid gametophytes from somatic tissues. Pollen is the male gametophyte and develops within the stamen; defects in the somatic tissues of the stamen and in the male ... -
Analysis of the miR319 target Zmtcptf24 in the maize inflorescence
(2014-12)Maize inflorescences are essential for reproduction and also produce seeds that are consumed as food. To understand the genetics pathways that control normal inflorescence development, we study mutants with abnormal ... -
Ancient gene transfer from algae to animals: Mechanisms and evolutionary significance
(2012)Background Horizontal gene transfer (HGT) is traditionally considered to be rare in multicellular eukaryotes such as animals. Recently, many genes of miscellaneous algal origins were discovered in choanoflagellates. ... -
Ancient Genome Duplications Did Not Structure the Human Hox-Bearing Chromosomes
(East Carolina University, 2001-05)The fact that there are four homeobox (Hox) clusters in most vertebrates but only one in invertebrates is often cited as evidence for the hypothesis that two rounds of genome duplication by polyploidization occurred early ... -
Androgen and progesterone receptor knockouts in Danio rerio affect aggression and social dominance (part 1)
(East Carolina University, 2018-12-07)It is well known that competition for the basic resources of food, shelter, and mates will always exist in nature. The most prevalent method of competing for such resources is aggression and social dominance. There is ... -
ANDROGEN AND PROGESTERONE RECEPTORS KNOCKOUTS IN ZEBRAFISH AFFECT AGGRESSION AND SOCIAL DOMINANCE
(East Carolina University, 2019-05-03)ABSTRACT - There is circumstantial evidence that steroids, such as androgens and progesterone, play roles in aggression and social behaviors in vertebrates. However, the genetic basis for these behaviors needs to be further ... -
Anti-Cancer Activity of Cucurbitacin IIa
(East Carolina University, 2012)Cancer is a debilitating disease resulting from uncontrolled proliferation. One major treatment strategy for cancer is the application of chemotherapeutic drugs which kill cancer cells. Cucurbitacins are a new family ...