Browsing Biology by Author "Capehart, Anthony A."
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Consequences of Reduced Versican Expression in Embryonic Chick Synovial Joint Development
Nagchowdhuri, Partha S. (East Carolina University, 2012)The different mechanisms involved in vertebrate synovial joint development are actively being uncovered. A variety of studies have thus far discovered the involvement of several large molecules in the processes of joint ... -
Effect of Versican G1 Domain Overexpression on Hyaluronan, Hyaluronidase-2, and Synovial Joint Formation in the Embryonic Chick
Andrews, Kristen Nichole (East Carolina University, 2013)Versican, an extracellular chondroitin sulfate proteoglycan which binds hyaluronan, has been hypothesized to play a role in synovial joint formation in the chick embryo. Several studies have shown versican to be involved ... -
Gamma Protocadherin Expression in the Embryonic Chick Nervous System
Cronin, Kenneth D.; Capehart, Anthony A. (East Carolina University, 2007)Protocadherin gamma (pcdh-gamma) family expression was examined in the embryonic chick central nervous system by in situ hybridization. Transcripts were visualized in discrete regions of fore-, mid-, and hindbrain at stages ... -
SPATIAL EXPRESSION OF MATRIX AND MATRIX RECEPTOR PROTEINS IN THE DEVELOPING SYNOVIAL JOINT
Robins, Joshua Eli (East Carolina University, 2013)Little is understood about the complex spatial and temporal molecular interactions necessary to form a fully functional synovial joint. Understanding molecular pathways and signaling within the developing joint continues ... -
Spatio-Temporal Expression of Chondroitin Sulfate Antigens in Early Chick Pituitary and Thyroid
Iyengar, Sheelah (East Carolina University, 2012)The chondroitin sulfate antigens d1C4 and TC2 have been hypothesized to play a role in cartilage differentiation in the limb and early morphogenesis of the heart in chick embryos. The antibody d1C4 recognizes a native ... -
VALIDATION OF CANDIDATE GENES IN RESPONSE TO VERSICAN MANIPULATION IN DEVELOPING SYNOVIAL JOINTS
Vick, Stephen (East Carolina University, 2012)Little is understood about the complex process of synovial joint formation in early limb development. It has been shown that versican is highly expressed in the extracellular matrix of these joints (Snow et al., 2005; ... -
Versican Expression during Synovial Joint Morphogenesis
Shepard, John B.; Krug, Heidi A.; LaFoon, Brooklynn A.; Hoffman, Stanley; Capehart, Anthony A. (East Carolina University, 2007-09)The extracellular matrix (ECM) plays a critical role in governing cell behavior and phenotype during limb skeletogenesis. Chondroitin sulfate proteoglycans (Cspgs) are highly expressed in the ECM of precartilage mesenchymal ...