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Three Generations, One Future: A Systematic Analysis on Nicotine's Effect across generations in C. elegans.
(East Carolina University, 2013)
Tobacco smoking is a worldwide epidemic that is responsible for diseases and death rates that surpass those attributed to a combination of other causes (e.g. cancer, HIV, accidents). A major mediator of tobacco-smoke related ...
Hydrogeomorphology and Horizontal Movement of Juncus roemerianus
(East Carolina University, 2015)
Juncus roemerianus, black needlerush, is common in high marshes and occasionally in low marshes along the Mid-Atlantic and southern USA. Previous work found that J. roemerianus patches remained relatively stable in the ...
Elucidating Gene Function with the use of Genome Wide Association Study (GWAS)
(East Carolina University, 2015)
DNA replication and cell proliferation are intensely studied subjects. There have been countless experiments and hours put into better understanding how DNA is replicated and compacted, and how cells are able to proliferate ...
Targeting aberrant signaling in the EGFR1/HER2/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway : Novel therapeutic interventions in breast cancer
(East Carolina University, 2015)
Breast cancer is attributed to being the second most deadly cancer in American women. Approximately 1 in 8 women will be diagnosed with breast cancer during her lifetime, and prognosis is dependent upon the genetic make-up ...
Physiological Studies of Alkaliphilic Anaerobic Organotrophs in a Serpentinizing Subsurface Habitat
(East Carolina University, 2014)
Microbial habitats in serpentinizing ultramafic rocks represent one of the largest, yet least understood portions of the biosphere, with potentially major consequences for global biogeochemical cycles. Serpentinization is ...
The Role of Transcription Factors Snail and Slug in Cardiac Myofibroblasts
(East Carolina University, 2014)
CCardiac fibrosis is a major facet contributing to cardiac dysfunction following a myocardial infarction. Persistent and excessive collagen deposition via cardiac myofibroblasts is the hallmark of cardiac fibrosis. Cardiac ...
PROLACTIN FUNCTION IN ZEBRAFISH DEVELOPMENT
(East Carolina University, 2010)
Extensive studies have implicated a myriad of functional roles for prolactin (PRL) and prolactin receptor (PRLR) across a variety of adult vertebrate species. However, much less is known about the physiological role(s) of ...
DERIVATION OF TOLEROGENIC THERAPEUTIC VACCINES FOR MOUSE MODELS OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(East Carolina University, 2012)
Multiple sclerosis (MS) is a chronic inflammatory disease that results in autoimmune demyelination of the human central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a widely-studied animal ...
Activation of GPR4 by acidosis inhibits tumor cell migration, invasion and metastasis.
(East Carolina University, 2011)
Melanoma and Prostate Cancer are two of the most diagnosed forms of cancer in the United States. The ability to metastasize and colonize in a distant location is one of the most devastating hallmarks of cancer as modes ...
Maturation, Fecundity, and Spawning Frequency of the Albemarle/Roanoke Striped Bass Stock
(East Carolina University, 2011)
The principal striped bass, Morone saxatilis population in North Carolina, the Albemarle/Roanoke (A/R) stock has grown tremendously in size and age structure over the last twenty years necessitating an up-to-date maturity ...