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Assessing cellular and genomic damage from environmental nickel using a GFP containing strain of Caenorhabditis elegans
(East Carolina University, 2013)
Nickel is a naturally found mineral that has become widely used for many electronic devices. As use and subsequent discarding of nickel containing products continues exposure to nickel increases. Nickel can cause external ...
THE EFFECT OF CHANGES IN SODIUM CONCENTRATIONS ON MITOCHONDRIA
(2015-05-01)
Atherosclerosis, hardening of the arteries, is the major cause of stroke, peripheral artery disease and heart attack. . Overproduction of superoxide anions in mitochondria can give rise to atherosclerosis. Superoxide anions ...
Hydrogeomorphology and Horizontal Movement of Juncus roemerianus
(East Carolina University, 2015)
Juncus roemerianus, black needlerush, is common in high marshes and occasionally in low marshes along the Mid-Atlantic and southern USA. Previous work found that J. roemerianus patches remained relatively stable in the ...
Elucidating Gene Function with the use of Genome Wide Association Study (GWAS)
(East Carolina University, 2015)
DNA replication and cell proliferation are intensely studied subjects. There have been countless experiments and hours put into better understanding how DNA is replicated and compacted, and how cells are able to proliferate ...
Targeting aberrant signaling in the EGFR1/HER2/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway : Novel therapeutic interventions in breast cancer
(East Carolina University, 2015)
Breast cancer is attributed to being the second most deadly cancer in American women. Approximately 1 in 8 women will be diagnosed with breast cancer during her lifetime, and prognosis is dependent upon the genetic make-up ...
Physiological Studies of Alkaliphilic Anaerobic Organotrophs in a Serpentinizing Subsurface Habitat
(East Carolina University, 2014)
Microbial habitats in serpentinizing ultramafic rocks represent one of the largest, yet least understood portions of the biosphere, with potentially major consequences for global biogeochemical cycles. Serpentinization is ...
The Role of Transcription Factors Snail and Slug in Cardiac Myofibroblasts
(East Carolina University, 2014)
CCardiac fibrosis is a major facet contributing to cardiac dysfunction following a myocardial infarction. Persistent and excessive collagen deposition via cardiac myofibroblasts is the hallmark of cardiac fibrosis. Cardiac ...
Physiological and Phylogenetic Studies of the Biogeography of Alkaliphilic Heterotrophic Bacteria from Serpentinizing Habitats
(East Carolina University, 2014)
Serpentinization occurs when ultramafic rocks containing the mineral olivine react with water to produce highly reducing conditions, which are commonly coincident with high concentrations of hydrogen. Hydrogen provides ...
Dodge, Duck, Dip, Dive & Dependence: Using Dodgeball to Explore Frequency Dependent Selection
(2016-09)
The term frequency dependence describes scenarios in which the likelihood
of an event occurring is strongly tied to how common a particular trait is.
Understanding frequency dependence is key to understanding ...
Clogging information flow in ALS
(2014-09-05)
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating neurodegenerative disorder that causes a progressive loss of motor neurons, leading to paralysis and death typically within 2 to 5 ...