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Investigating the Interaction of RecQL4 and Mcm10 in Drosophila melanogaster
(East Carolina University, 2014)
Accurate duplication and regulation of the eukaryotic genome requires precise coordination among multiple replication factors. RecQL4, the least characterized RecQ protein, is a 1208 amino acid protein containing a centrally ...
Fishing For The Evolutionary Bases Of Female Ornamentation
(East Carolina University, 2015)
Sexual dimorphism, or phenotypic differentiation of the sexes, is widespread amongst animals. It is understood mainly in the context of sexual selection, i.e. selection on mating success, with such selection typically ...
REPRODUCTIVE ISOLATION AND MIMETIC DIVERGENCE IN THE POISON FROG RANITOMEYA IMITATOR
(East Carolina University, 2014)
Understanding the process of speciation requires examination of various stages of its progress. This work focuses on the early stages of population divergence, where populations of a single species may show varying levels ...
HUMAN T-CELL LEUKEMIA VIRUS TYPE 1-ENCODED PROTEIN HBZ INCREASES VIRAL INFECTION
(East Carolina University, 2017-05-04)
Human T-lymphotropic virus type 1 (HTLV-1) is a complex retrovirus, infecting CD4+ T lymphocytes. About 10 million people worldwide are infected with HTLV-1. HTLV-1 has been linked to adult T-cell leukemia (ATL), a disease ...
The Role of Pre-Replication Complex Proteins in Drosophila Ovarian Stem Cell Maintenance and Proliferation
(East Carolina University, 2017-05-05)
Cancer stem cells (CSCs) may hold the key to advances in cancer research. Like adult tissue-specific stem cells, CSCs are able to self-renew and last a lifetime. These shared characteristics can thus be used to help learn ...
INVESTIGATING THE MOLECULAR CONTROL OF ECDYSONE RESPONSE GENE, E74, IN THE DROSOPHILA OVARY.
(East Carolina University, 2017-05-05)
Oogenesis is the process by which an egg develops from precursor cells in the ovary. This process has been widely studied; however, many of the molecular mechanisms that regulate oocyte development and growth remain unclear. ...
Prevention of synaptic loss in cortico-hippocampal culture by silencing Kremen1 with siRNA
(East Carolina University, 2017-05-19)
Research has shown that Alzheimer’s disease could be a result of an accumulation of amyloid β (Aβ) plaques and tau protein. The accumulation of Aβ activates p53, which leads to an increase of Dickkopf-1 (Dkk1). When Dkk1 ...
How do modified nanoclays adversely affect aquatic species relative to natural nanoclay?
(East Carolina University, 2017-07-17)
Nanoclays represent a large class of modified nanomaterials (NMs) (i.e. nanoscale particles from 1 to 100 nm) that has received great attention from the scientific and industrial communities. This material has been widely ...
Sexual Dimorphism and Trophic Trait Evolution in the Carolina Bay Fundulus Complex
(East Carolina University, 2017-01-05)
Convergent evolution in similar environments is widely held to provide some of the strongest evidence for natural selection's role in evolution, and convergent or parallel evolution of reproductive isolation, best studied ...
Impact of Vessel Noise on Oyster Toadfish (Opsanus tau) Behavior and Implications for Underwater Noise Management
(East Carolina University, 2017-05-03)
Underwater noise and its impacts on marine life are growing management concerns. This dissertation considers both the ecological and social concerns of underwater noise, using the oyster toadfish (Opsanus tau) as a model ...