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Nicotine exposure and transgenerational impact: a prospective study on small regulatory microRNAs
(2014-12-17)
Early developmental stages are highly sensitive to stress and it has been reported that pre-conditioning with tobacco smoking during adolescence predisposes those youngsters to become smokers as adults. However, the molecular ...
Analysis of the miR319 target Zmtcptf24 in the maize inflorescence
(2014-12)
Maize inflorescences are essential for reproduction and also produce seeds that are consumed as food. To understand the genetics pathways that control normal inflorescence development, we study mutants with abnormal ...
MHC class I variation among wild, domestic and insular populations of the zebra finch (Taeniopygia guttata)
(East Carolina University, 2014)
The zebra finch (Taeniopygia guttata) is a passerine bird native to Australia and the Lesser Sunda Islands, with domesticated populations derived from each of these localities. The Lesser Sundas and domesticated zebra ...
RNA polymerase II CTD Evolutionary Diversity and Associated Protein Identification in Green and Red Algae
(East Carolina University, 2014)
In model eukaryotes, the C-terminal domain (CTD) of the largest subunit (RPB1) of DNA-dependent RNA polymerase II is composed of tandemly repeated heptads with the consensus sequence YSPTSPS. Both the core motif and tandem ...
An assessment of the polytypic status of the Namib darkling beetles Onymacris unguicularis and Onymacris rugatipennis
(2014-12-10)
The southern African beetle genus Onymacris (family Tenebrionidae) comprises 14 species, six of which are polytypic. Despite longstanding research on the physiological and behavioral adaptations of these desert beetles, ...
Investigating the Interaction of RecQL4 and Mcm10 in Drosophila melanogaster
(East Carolina University, 2014)
Accurate duplication and regulation of the eukaryotic genome requires precise coordination among multiple replication factors. RecQL4, the least characterized RecQ protein, is a 1208 amino acid protein containing a centrally ...
A Comprehensive Approach to Identify Reliable Reference Gene Candidates to Investigate the Link between Alcoholism and Endocrinology in Sprague-Dawley Rats
(2014)
Gender and hormonal differences are often correlated with alcohol dependence and related complications like addiction and breast cancer. Estrogen (E2) is an important sex hormone because it serves as a key protein involved ...
Species-Specific Expansion and Molecular Evolution of the 3-hydroxy-3-methylglutaryl Coenzyme A Reductase (HMGR) Gene Family in Plants
(2014)
Kazakh dandelion (Taraxacum kok-saghyz, Tk) is a rubber-producing plant currently being investigated as a source of natural rubber for industrial applications. Like many other isoprenoids, rubber is a downstream product ...
Alkaloid defenses of co-mimics in a putative Müllerian mimetic radiation
(2014)
Background
Polytypism in aposematic species is unlikely according to theory, but commonly seen in nature. Ranitomeya imitator is a poison frog species exhibiting polytypic mimicry of three congeneric model species (R. ...
Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes
(2014-08)
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by ...