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Genome-wide and molecular evolution analysis of the subtilase gene family in
(2014-12)
Background
Vitis vinifera (grape) is one of the most economically significant fruit crops in the world. The availability of the recently released grape genome sequence offers an opportunity to identify and analyze some ...
Genome sequencing and analysis of the paclitaxel-producing endophytic fungus NRRL 62431
(2014)
Background
Paclitaxel (Taxol™) is an important anticancer drug with a unique mode of action. The biosynthesis of paclitaxel had been considered restricted to the Taxus species until it was discovered in Taxomyces andreanae, ...
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial
(2014-08)
Background: B vitamins play an important role in homocysteine metabolism, with vitamin deficiencies resulting in increased levels of homocysteine and increased risk for stroke. We performed a genome-wide association study ...
Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of with Ischemic Stroke
(2014-03)
Circulating homocysteine levels (tHcy), a product of the folate one carbon metabolism pathway (FOCM) through the demethylation of methionine, are heritable and are associated with an increased risk of common diseases such ...
Brain size varies with temperature in vertebrates
(2014-03)
The tremendous variation in brain size among vertebrates has long been thought to be related to differences in species’ metabolic rates. It is thought that species with higher metabolic rates can supply more energy to ...
Carl Woese, Dick Young, and the roots of astrobiology
(2014-03)
The beginning of the space age in the late 1950s gave rise to innovative and interdisciplinary research concepts and perspectives, including the concept of “exobiology” as a way to approach the fundamental aspects of biology ...
The Acquisition of a Plastid by Haptophytes, Cryptophytes, and Photosynthetic Heterokonts
(East Carolina University, 2014)
Red algae and green plants are known to have obtained their photosynthetic organelles, or plastids, through the endosymbiotic adoption of cyanobacteria. It is still widely debated as to how other eukaryotic alga such as ...
The Effects of Crude Oil and Chemical Dispersant Exposure on Danio rerio (zebrafish) Embryonic Development
(East Carolina University, 2014)
Crude oil has been shown to cause defects in cardiovascular development in a variety of teleost species. We used the zebrafish, Danio rerio as a model to test the effects of oil and dispersant on cardiac development and ...
Spatial Ecology and Seasonal Habitat Use of the King Rail (Rallus elegans) along the Atlantic Coast
(East Carolina University, 2014)
TThe King Rail (Rallus elegans) continues to experience population declines throughout its range. Due to its secretive nature and occupancy of densely vegetated marshes, little is known about the behavior and ecology of ...