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Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer
(East Carolina University, 2012)
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Pancreatic tumors over-express the protein mesothelin, and therefore, it is used as a tumor target antigen for vaccine development. ...
MICROBIAL DIVERSITY AND BIOGEOGRAPHY IN A SERPENTINITE-HOSTED ECOSYSTEM
(East Carolina University, 2010)
The goal of this project was to characterize the taxonomic and functional diversity and document biogeographic patterns of microbial communities in an ecosystem influenced by active serpentinization. Serpentinization is a ...
Microbial Carbon Assimilation within the Walls of Deep-sea Hydrothermal Vent Chimneys
(East Carolina University, 2011)
Carbon is one of the most abundant elements on Earth stored in a multitude of reservoirs and constantly cycled through various processes occurring on our planet. Although it represents only a small percentage of the total ...
Physiological Studies of Alkaliphilic Anaerobic Organotrophs in a Serpentinizing Subsurface Habitat
(East Carolina University, 2014)
Microbial habitats in serpentinizing ultramafic rocks represent one of the largest, yet least understood portions of the biosphere, with potentially major consequences for global biogeochemical cycles. Serpentinization is ...
Physiological and Phylogenetic Studies of the Biogeography of Alkaliphilic Heterotrophic Bacteria from Serpentinizing Habitats
(East Carolina University, 2014)
Serpentinization occurs when ultramafic rocks containing the mineral olivine react with water to produce highly reducing conditions, which are commonly coincident with high concentrations of hydrogen. Hydrogen provides ...
Effects Of Nutrient Availability And Disturbance On The Composition And Diversity Of Soil Microorganisms
(East Carolina University, 2015)
Determining how factors such as disturbance and nutrient availability affect species diversity in a community has been a major goal of community ecology. The purpose of this study was to look at how species diversity and ...
Investigating the Microbial Communities Associated with Aluminum Alloys 2024 and 7075
(East Carolina University, 2020-11-17)
Aluminum (Al), one of the most versatile, cost-effective, and appealing metals for use in construction, has no known biological function. Al alloys in aquatic environments provide a surface for attachment and can be ...
The Fur-like regulator Mur controls the expression of the gene encoding the manganese transporter MntH in Brucella abortus 2308 in response to manganese availability
(East Carolina University, 2011)
Brucella abortus is a Gram-negative, [alpha]-proteobacterium that causes bovine brucellosis, a prevalent zoonotic disease in many areas of the world. Brucella abortus is an intracellular pathogen that survives and ...
Molecular Epidemiology of MRSA Among Patients and Employees in a Surgical Intensive Care Unit
(East Carolina University, 2011)
Methicillin-resistant Staphylococcus aureus (MRSA) is a pervasive drug resistant human pathogen and has become widespread in hospitals around the world. MRSA infections cause approximately 19,000 deaths among hospitalized ...
Transcriptional Analysis of the Bacteroides fragilis Starch Utilization Operon, osuA
(East Carolina University, 2011)
The opportunistic pathogen Bacteroides fragilis is a symbiotic organism that inhabits the human gastrointestinal tract where it utilizes dietary and host-derived polysaccharides as carbon and energy sources. If abdominal ...