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    Late gastrointestinal tissue effects after hypofractionated radiation therapy of the pancreas

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    Author
    Elhammali, Adnan; Patel, Mukund; Weinberg, Benjamin; Verma, Vivek; Liu, Jingxia; Olsen, Jeffrey R.; Gay, Hiram A.
    Abstract
    Background To consolidate literature reports of serious late gastrointestinal toxicities after hypofractionated radiation treatment of pancreatic cancer and attempt to derive normal tissue complication probability (NTCP) parameters using the Lyman-Kutcher-Burman model. Methods Published reports of late grade 3 or greater gastrointestinal toxicity after hypofractionated treatment of pancreatic cancer were reviewed. The biologically equivalent dose in 1.8 Gy fractions was calculated using the EQD model. NTCP parameters were calculated using the LKB model assuming 1–5 % of the normal tissue volume was exposed to the prescription dose with α/β ratios of 3 or 4. Results A total of 16 human studies were examined encompassing a total of 1160 patients. Toxicities consisted of ulcers, hemorrhages, obstructions, strictures, and perforations. Non-hemorrhagic and non-perforated ulcers occurred at a rate of 9.1 % and were the most commonly reported toxicity. Derived NTCP parameter ranges were as follows: n = 0.38–0.63, m = 0.48–0.49, and TD50 = 35–95 Gy. Regression analysis showed that among various study characteristics, dose was the only significant predictor of toxicity. Conclusions Published gastrointestinal toxicity reports after hypofractionated radiotherapy for pancreatic cancer were compiled. Median dose was predictive of late grade ≥ 3 gastrointestinal toxicity. Preliminary NTCP parameters were derived for multiple volume constraints.
    URI
    http://hdl.handle.net/10342/5726
    Date
    2015-09
    Citation:
    APA:
    Elhammali, Adnan, & Patel, Mukund, & Weinberg, Benjamin, & Verma, Vivek, & Liu, Jingxia, & Olsen, Jeffrey R., & Gay, Hiram A.. (September 2015). Late gastrointestinal tissue effects after hypofractionated radiation therapy of the pancreas. Radiation Oncology (London, England), (10:186), p.1-8. Retrieved from http://hdl.handle.net/10342/5726

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    MLA:
    Elhammali, Adnan, and Patel, Mukund, and Weinberg, Benjamin, and Verma, Vivek, and Liu, Jingxia, and Olsen, Jeffrey R., and Gay, Hiram A.. "Late gastrointestinal tissue effects after hypofractionated radiation therapy of the pancreas". Radiation Oncology (London, England). 10:186. (1-8.), September 2015. March 06, 2021. http://hdl.handle.net/10342/5726.
    Chicago:
    Elhammali, Adnan and Patel, Mukund and Weinberg, Benjamin and Verma, Vivek and Liu, Jingxia and Olsen, Jeffrey R. and Gay, Hiram A., "Late gastrointestinal tissue effects after hypofractionated radiation therapy of the pancreas," Radiation Oncology (London, England) 10, no. 186 (September 2015), http://hdl.handle.net/10342/5726 (accessed March 06, 2021).
    AMA:
    Elhammali, Adnan, Patel, Mukund, Weinberg, Benjamin, Verma, Vivek, Liu, Jingxia, Olsen, Jeffrey R., Gay, Hiram A.. Late gastrointestinal tissue effects after hypofractionated radiation therapy of the pancreas. Radiation Oncology (London, England). September 2015; 10(186) 1-8. http://hdl.handle.net/10342/5726. Accessed March 06, 2021.
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