Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer

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Author
Nguyen, Nam P.; Vos, Paul; Vinh-Hung, Vincent; Ceizyk, Misty; Smith-Raymond, Lexie; Stevie, Michelle; Slane, Benjamin; Chi, Alexander; Desai, Anand; Krafft, Shane P.; Jang, Siyoung; Hamilton, Russ; Karlsson, Ulf; Abraham, Dave
Abstract
Background To evaluate the feasibility of image-guided radiotherapy based on helical Tomotherapy to spare the contralateral parotid gland in head and neck cancer patients with unilateral or no neck node metastases. Methods A retrospective review of 52 patients undergoing radiotherapy for head and neck cancers with image guidance based on daily megavoltage CT imaging with helical tomotherapy was performed. Results Mean contralateral parotid dose and the volume of the contralateral parotid receiving 40 Gy or more were compared between radiotherapy plans with significant constraint (SC) of less than 20 Gy on parotid dose (23 patients) and the conventional constraint (CC) of 26 Gy (29 patients). All patients had PTV coverage of at least 95% to the contralateral elective neck nodes. Mean contralateral parotid dose was, respectively, 14.1 Gy and 24.7 Gy for the SC and CC plans (p < 0.0001). The volume of contralateral parotid receiving 40 Gy or more was respectively 5.3% and 18.2% (p < 0.0001) Conclusion Tomotherapy for head and neck cancer minimized radiotherapy dose to the contralateral parotid gland in patients undergoing elective node irradiation without sacrificing target coverage.
URI
http://hdl.handle.net/10342/5740
Subject
 Head and neck cancer; Tomotherapy; Parotid sparing 
Date
2012
Citation:
APA:
Nguyen, Nam P., & Vos, Paul, & Vinh-Hung, Vincent, & Ceizyk, Misty, & Smith-Raymond, Lexie, & Stevie, Michelle, & Slane, Benjamin, & Chi, Alexander, & Desai, Anand, & Krafft, Shane P., & Jang, Siyoung, & Hamilton, Russ, & Karlsson, Ulf, & Abraham, Dave. (January 2012). Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer. BMC Cancer, (175-175. Retrieved from http://hdl.handle.net/10342/5740

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MLA:
Nguyen, Nam P., and Vos, Paul, and Vinh-Hung, Vincent, and Ceizyk, Misty, and Smith-Raymond, Lexie, and Stevie, Michelle, and Slane, Benjamin, and Chi, Alexander, and Desai, Anand, and Krafft, Shane P., and Jang, Siyoung, and Hamilton, Russ, and Karlsson, Ulf, and Abraham, Dave. "Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer". BMC Cancer. . (175-175.), January 2012. July 10, 2020. http://hdl.handle.net/10342/5740.
Chicago:
Nguyen, Nam P. and Vos, Paul and Vinh-Hung, Vincent and Ceizyk, Misty and Smith-Raymond, Lexie and Stevie, Michelle and Slane, Benjamin and Chi, Alexander and Desai, Anand and Krafft, Shane P. and Jang, Siyoung and Hamilton, Russ and Karlsson, Ulf and Abraham, Dave, "Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer," BMC Cancer 12, no. (January 2012), http://hdl.handle.net/10342/5740 (accessed July 10, 2020).
AMA:
Nguyen, Nam P., Vos, Paul, Vinh-Hung, Vincent, Ceizyk, Misty, Smith-Raymond, Lexie, Stevie, Michelle, Slane, Benjamin, Chi, Alexander, Desai, Anand, Krafft, Shane P., Jang, Siyoung, Hamilton, Russ, Karlsson, Ulf, Abraham, Dave. Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer. BMC Cancer. January 2012; 12() 175-175. http://hdl.handle.net/10342/5740. Accessed July 10, 2020.
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