Unusual reticulin staining pattern in well-differentiated hepatocellular carcinoma
Author
Hong, Heng; Patonay, Bryan; Finley, James
Abstract
Background
Special stains, such as reticulin stain and CD34 immunostain, are very helpful in the diagnosis of well differentiated hepatocellular carcinoma (HCC). Most studies have shown that absent or decreased reticulin stain or an abnormal reticulin pattern with widened trabeculae is reliable for the diagnosis of well-differentiated HCC.
Case report
We report here two cases of well differentiated HCC with an unusual reticulin staining pattern. A strongly positive reticulin network was preserved within the tumor, which surrounded individual tumor cells in a monolayered trabecular pattern. At the same time, an increased CD34 stain was present in the tumor.
Conclusions
This unusual reticulin pattern represents part of the diverse reticulin staining patterns seen in HCC. Although this staining pattern is rare, it should be recognized when diagnosing well-differentiated HCC in small samples such as cellblock of fine needle aspiration or small core biopsies.
Date
2011
Citation:
APA:
Hong, Heng, & Patonay, Bryan, & Finley, James. (January 2011).
Unusual reticulin staining pattern in well-differentiated hepatocellular carcinoma.
Diagnostic Pathology,
6(),
15-
15. Retrieved from
http://hdl.handle.net/10342/5743
MLA:
Hong, Heng, and Patonay, Bryan, and Finley, James.
"Unusual reticulin staining pattern in well-differentiated hepatocellular carcinoma". Diagnostic Pathology.
6:. (15-15),
January 2011.
September 21, 2023.
http://hdl.handle.net/10342/5743.
Chicago:
Hong, Heng and Patonay, Bryan and Finley, James,
"Unusual reticulin staining pattern in well-differentiated hepatocellular carcinoma," Diagnostic Pathology 6, no.
(January 2011),
http://hdl.handle.net/10342/5743 (accessed
September 21, 2023).
AMA:
Hong, Heng, Patonay, Bryan, Finley, James.
Unusual reticulin staining pattern in well-differentiated hepatocellular carcinoma. Diagnostic Pathology.
January 2011;
6():
15-15.
http://hdl.handle.net/10342/5743. Accessed
September 21, 2023.
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