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    Unusual reticulin staining pattern in well-differentiated hepatocellular carcinoma

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    Author
    Hong, Heng; Patonay, Bryan; Finley, James
    Abstract
    Background Special stains, such as reticulin stain and CD34 immunostain, are very helpful in the diagnosis of well differentiated hepatocellular carcinoma (HCC). Most studies have shown that absent or decreased reticulin stain or an abnormal reticulin pattern with widened trabeculae is reliable for the diagnosis of well-differentiated HCC. Case report We report here two cases of well differentiated HCC with an unusual reticulin staining pattern. A strongly positive reticulin network was preserved within the tumor, which surrounded individual tumor cells in a monolayered trabecular pattern. At the same time, an increased CD34 stain was present in the tumor. Conclusions This unusual reticulin pattern represents part of the diverse reticulin staining patterns seen in HCC. Although this staining pattern is rare, it should be recognized when diagnosing well-differentiated HCC in small samples such as cellblock of fine needle aspiration or small core biopsies.
    URI
    http://hdl.handle.net/10342/5743
    Date
    2011
    Citation:
    APA:
    Hong, Heng, & Patonay, Bryan, & Finley, James. (January 2011). Unusual reticulin staining pattern in well-differentiated hepatocellular carcinoma. Diagnostic Pathology, (15-15. Retrieved from http://hdl.handle.net/10342/5743

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    MLA:
    Hong, Heng, and Patonay, Bryan, and Finley, James. "Unusual reticulin staining pattern in well-differentiated hepatocellular carcinoma". Diagnostic Pathology. . (15-15.), January 2011. April 20, 2021. http://hdl.handle.net/10342/5743.
    Chicago:
    Hong, Heng and Patonay, Bryan and Finley, James, "Unusual reticulin staining pattern in well-differentiated hepatocellular carcinoma," Diagnostic Pathology 6, no. (January 2011), http://hdl.handle.net/10342/5743 (accessed April 20, 2021).
    AMA:
    Hong, Heng, Patonay, Bryan, Finley, James. Unusual reticulin staining pattern in well-differentiated hepatocellular carcinoma. Diagnostic Pathology. January 2011; 6() 15-15. http://hdl.handle.net/10342/5743. Accessed April 20, 2021.
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