Browsing Chemistry by Title
Now showing items 108-120 of 120
-
Thermodynamic Investigation of Copper Binding to the Amyloid-Beta (A[beta]) Peptide
(East Carolina University, 2010)Alzheimer's disease is a fatal and neurodegenerative disease with as many as 5.3 million Americans living with the disease. One of the characteristic hallmarks of Alzheimer's is the amyloid plaques that build up around the ... -
Thermodynamic Investigations into Copper Binding in the N-Terminal Region of the Prion Protein at Low Copper Loadings
(East Carolina University, 2010)The prion protein (PrP) is a naturally occurring protein found at high levels in central nervous system (CNS). The misfolding of the PrP is responsible for neurodegenerative diseases called transmissible spongioform ... -
Thermodynamic studies of Ca²⁺ binding to human cardiac troponin C
(East Carolina University, 2012)Human Cardiac Troponin C (HcTnC) is an EF hand protein responsible for initiating contraction of the myocardium (heart muscle). The helix-loop-helix motif, characteristic of members of the EF-hand family, allows HcTnC to ... -
Tissue lockable connecting structures
(2006-08-01)Percutaneous skin access devices include a plurality of locked connecting units mounted to the exterior surface of an implantable medical object which, in position, is configured to penetrate the skin of a subject. The ... -
Towards Establishing Methods of Synthesis, Purification, and Structural Determination for Human Fibrinogen
(East Carolina University, 2023-05-04)Fibrinogen is a prevalent blood-based glycoprotein. In its polymerizable form, fibrin, it serves as the structural component of blood clots and helps to incorporate red blood cells, macrophages, and fibroblasts to the ... -
Transthyretin Amyloidosis: Proteolytic cleavage accelerates G53A TTR misfolding and aggregation
(East Carolina University, 2020-06-22)The proteolytic cleavage of the peptide bond Lys48-Thr49 of the CD loop in TTR pathological mutants S52P and E51_S52dup was previously demonstrated to promote aggregation as a result of tetrameric structure destabilization. ... -
Using Fluorescence and Infrared Spectroscopy to Analyze the Interaction of Disaccharides with Lipid Bilayers
(East Carolina University, 2018-07-24)It is well known that sugars, such as trehalose, dehydrate lipid membranes based upon the Water Replacement Hypothesis. Here, we have investigated the interaction between different sugars (sucralose, sucrose, and trehalose) ... -
Using Fluorescent Probes to Study the Location and Interaction of Disaccharides within Lipid Bilayers
(East Carolina University, 2016-04-26)It is well known that certain organisms, such as the tardigrade, are capable of surviving extreme conditions including dehydration, freezing and / or oxygen deficiency. The tardigrades ability to withstand such extreme ... -
Using LC/MS to Quantify Metabolites in Urine Samples Post Clinical Exposure to Benzoates in Beverages
(East Carolina University, 2018-05-01)Evidence has suggested that benzoate consumption has the potential to cause weight loss prevention. Benzoate is conjugated with glycine in the mitochondrial matrix to form hippurate which is eliminated in urine. IRB approval ... -
Utilizing Isothermal Titration Calorimetry to Quantify the Thermodynamics of Cadmium Mimicry: A Comparison to Calcium
(East Carolina University, 2016-07-20)Isothermal titration calorimetry (ITC) is a powerful calorimetric method which can determine all thermodynamic parameters (K, [Delta]H, [Delta]G, and [Delta]S) for a binding event in a single experiment. More recently, ITC ... -
WATER-SOLUBLE FLUORESCENT PH SENSORS BASED ON A DIARYLACETYLENE SCAFFOLD
(East Carolina University, 2010)Intracellular pH plays an important role in many biological processes: receptor-mediated signal transduction, enzymatic activity, cell growth and death, ion transport and homeostasis, calcium regulation, endocytosis, ... -
Wurster's crown ligands
(2002-08-27)Wurster's crown ligands comprise a macrocyclic ligand such as a crown ether in which a hetero atom is substituted with a 1,4-phenylenediamine group. The phenylenediamine group is covalently bound to the macrocyclic ligand ... -
Wurster's crown ligands
(2001-07-17)Wurster's crown ligands comprise a macrocyclic ligand such as a crown ether in which a hetero atom is substituted with a 1,4-phenylenediamine group. The phenylenediamine group is covalently bound to the macrocyclic ligand ...