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THE SYNTHESIS, STRUCTURE AND PHOTOPHYSICAL PROPERTIES OF PHOSPHORESCENT CYCLOMETALATED N^N^C-COORDINATED PLATINUM COMPLEXES
(East Carolina University, 2016-07-25)
Phosphorescent materials based on cyclometalated platinum complexes have attracted a great deal of attention because of their potential in chemical, biological and optoelectronic applications, specifically as emitters in ...
Electrochemical Detection of Benzo[a]Pyrene-Induced DNA Damage at TP53 Oligomers : Impact of 5'-Methyl Cytosine and Bioactivation on the Genotoxicity Process
(East Carolina University, 2014)
DNA houses the blueprint that dictates how an organism will develop. However, DNA features numerous reactive sites that can be attacked by chemicals and radiation, resulting in DNA damage and possibly mutations. Chemical ...
protaTETHER – a method for the incorporation of variable linkers in protein fusions reveals impacts of linker flexibility in a PKAc‐GFP fusion protein
(2018-03-14)
Protein fusions are of fundamental importance in the study of cellular biology and the elucidation of cell signaling pathways, and the importance of linkers for the proper function of protein fusions is well documented in ...
Heavy Metal Concentrations in Biofluid Samples and their Correlation to Metabolic Syndrome
(East Carolina University, 2018-05-01)
The goal of this project was to determine if toxic metals such as Cr, Mn, As, Ni, Cd, and Pb are stored in the adipose tissue of farm animals, in particular swine. To detect these trace elements, a method of extraction and ...
Membrane Localization of Pyrene-Trehalose Conjugates (PYRETs)
(East Carolina University, 2018-05-01)
The disaccharide trehalose is found in many organisms that can survive in extremely cold or dry environments. According to the “hydration hypothesis,” trehalose interacts with the glycerol/phosphate regions of lipid bilayers ...
Using LC/MS to Quantify Metabolites in Urine Samples Post Clinical Exposure to Benzoates in Beverages
(East Carolina University, 2018-05-01)
Evidence has suggested that benzoate consumption has the potential to cause weight loss prevention. Benzoate is conjugated with glycine in the mitochondrial matrix to form hippurate which is eliminated in urine. IRB approval ...
Detection of Environmental DNA Damage Using Electrochemical Sensors and Mass Spectrometry
(East Carolina University, 2018-05-04)
Nickel exposure has been linked to a variety of health complications including instances of tumors and cancer in living organisms. Exposure to nickel can occur due to pollution from mining or industrial applications. ...
Using Fluorescence and Infrared Spectroscopy to Analyze the Interaction of Disaccharides with Lipid Bilayers
(East Carolina University, 2018-07-24)
It is well known that sugars, such as trehalose, dehydrate lipid membranes based upon the Water Replacement Hypothesis. Here, we have investigated the interaction between different sugars (sucralose, sucrose, and trehalose) ...
Counting Protons: Using Isothermal Titration Calorimetry to Determine the Number of Protons Exchanged Upon Ca(II) and Cd(II) Binding to Wild-type HcTnC and Mutant C84A and C35A/C84A Proteins
(East Carolina University, 2018-07-20)
Maintaining a delicate balance of metal ions in the cell is crucial to the survival of many organisms. Divalent cadmium, Cd(II), is a non-essential metal ion that can disrupt this delicate balance and lead to deleterious ...
SEPARATION AND ANALYSIS OF PRESERVATIVES IN SKINCARE CREAMS BY HIGH TEMPERATURE LIQUID CHROMATOGRAPHY AND SUBCRITICAL WATER CHROMATOGRAPHY
(East Carolina University, 2011)
Preservatives are chemicals with antimicrobial activity commonly added to foods, pharmaceuticals and cosmetics in order to prolong products' shelf life and to protect the consumer from potential infection. Parabens, the ...