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Now showing items 11-20 of 20
Subcritical Water Extraction of Salvia miltiorrhiza
(2021-03-15)
Developing Novel Chemotherapeutics: A Structure-Activity Study of Anandamide Analogs and their Cytotoxic Profiles
(East Carolina University, 2020-01-06)
Many epithelial cancers have been shown to overexpress the enzyme cyclooxygenase-2 (COX-2), an enzyme responsible for both the metabolism of arachidonic acid (AA) to prostaglandins and arachidonoyl ethanolamine (AEA) to ...
Transthyretin Amyloidosis: Proteolytic cleavage accelerates G53A TTR misfolding and aggregation
(East Carolina University, 2020-06-22)
The proteolytic cleavage of the peptide bond Lys48-Thr49 of the CD loop in TTR pathological mutants S52P and E51_S52dup was previously demonstrated to promote aggregation as a result of tetrameric structure destabilization. ...
GRADUATE TEACHING ASSISTANT FIDELITY OF IMPLEMENTATION IN INTRODUCTORY CHEMISTRY AND PHYSICS LABORATORIES: IMPACT ON SCIENCE PRACTICE PROFICIENCY
(East Carolina University, 2020-06-22)
This study reports the fidelity of implementation of the Argument-Driven Inquiry (ADI) instructional model by graduate teaching assistants (GTAs) in introductory chemistry and introductory physics laboratories at East ...
A Carbohydrate/Lipid Research Project for Organic and Analytical CURE Laboratories: Reactions and Recordkeeping
(East Carolina University, 2021-05-06)
Course-based Undergraduate Research Experiences (or CUREs) are able to teach students laboratory skills while engaging them in novel research. The first part of this thesis aims to demonstrate the development of a feasible ...
DIRECT ELECTROCHEMICAL ANALYSIS OF THE REDOX ACTIVITY OF TRYPTOPHAN AND TYROSINE IN MODIFIED AZURINS: THE IMPACT OF THE PROTEIN ENVIRONMENT
(East Carolina University, 2021-05-03)
Proton-coupled electron transfer (PCET) is a biological process essential to life. It is imperative for respiration in animals as well as photosynthesis in plants. Long-range PCET is often facilitated by redox-active amino ...