Search
Now showing items 21-30 of 87
EXPLORING STUDENT EXPERIENCES ACROSS A LINKED SEQUENCE COURSE-BASED UNDERGRADUATE RESEARCH EXPERIENCE
(East Carolina University, 2020-11-23)
This study reports the effect a linked Course-based Undergraduate Research Experience (CURE) has on a students' understanding of research and the associated experiences they encountered. CUREs offer an alternative path to ...
Studying Collagen with PyrATS: Pyrene-Appended Trimeric Systems
(East Carolina University, 2019-07-30)
Collagens are a family of triple-helical structural proteins that are ubiquitous in vertebrates. Improper folding of collagen can lead to disorders such as osteogenesis imperfecta, or "brittle bone disease." There is ...
Modern and Classic Quantum Chemistry: Modeling Rhodium-Catalyzed Hydroacylation with Advanced Tools and the Development and Application of Software to Examine Simple Bonding Interactions in a Basis of Molecular Fragments
(East Carolina University, 8/5/2020)
In this dissertation, both modern and classic computational methods are utilized to examine two problems of interest in the field of chemistry. The first problem involves a complex rhodium-catalyzed hydroacylation reaction ...
HOW CHARGED RESIDUES INFLUENCE THE THERMAL STABILITY OF COLLAGEN: A STUDY WITH NATURAL AND NON-NATURAL AMINO ACIDS
(East Carolina University, 2020-09-16)
Triple-helical collagens are key structural proteins in mammals. Their ubiquity and diverse functions drive our interest into understanding their behavior at a fundamental level. This thesis describes a reductionist approach ...
EXPLORATION INTO THE SCOPE AND MECHANISM OF THE PLATINUM-CATALYZED ACYLATION OF 2-(ARYLOXY)PYRIDINES
(East Carolina University, 2019-07-11)
Transition metal catalysts have played a key role in direct C-H bond functionalization. However, one main drawback of these reactions is that oxidants and additives are often required to regenerate the active catalyst, ...
Computational Investigation of Calcium Binding Proteins Annexin A1 and Cardiac Troponin C
(East Carolina University, 2019-07-15)
Calcium binding proteins are vital for many biological functions. Many undergo calcium induced conformation changes through sensing motifs, resulting in functional changes for the proteins. In this study computational ...
THE IMPACT OF GLYCOSYLATION ON ACTIVE SITE STRUCTURE AND ACTIVITY IN THE FUNGUS ENZYME MOLOX
(East Carolina University, 2019-05-01)
Lipoxygenases from pathogenic fungi belong to the lipoxygenase family that catalyze the C-H activation of polyunsaturated fatty acids to form diverse hydroperoxides. While the lipoxygenase catalytic domains are structurally ...
Elucidating the Mechanisms of Transthyretin Aggregation in Transthyretin Amyloidosis
(East Carolina University, 2018-07-24)
Accumulation of insoluble aggregates (amyloids) is a characteristic feature of many neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Aggregation and deposition of Transthyretin (TTR) protein ...
THE DEVELOPMENT OF BETA-ACTIN MUTANTS WITH ALTERED BINDING AFFINITES FOR ATP AND ADP
(East Carolina University, 2018-12-10)
A number of neurodegenerative diseases are accompanied by the formation of cofilin-actin rods in neural cells. These rods can cause synaptic dysfunction and block transport within neurites. The overall goal of this project ...
Kinetic Modeling of Batch Reaction Processes
(East Carolina University, 2012)
Kinetic models have been demonstrated to be useful in on-line batch monitoring systems. The ability to monitor a reaction in real time is invaluable to the production process of industrial and pharmaceutical products. ...