• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Dissertations and Theses
    • Dissertations
    • View Item
    •   ScholarShip Home
    • Dissertations and Theses
    • Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Protection and Sensitization of Human Cells to Proton Radiation by Cerium Oxide Nanoparticles

    Thumbnail
    View/ Open
    CARLSON-DOCTORALDISSERTATION-2017.pdf (6.108Mb)

    Show full item record
    Author
    Carlson, Nathan B
    Abstract
    In radiation therapy for the treatment of cancer, there is demand for novel approaches that will improve tumor cell killing while protecting healthy tissue. One such approach that has shown considerable promise is the application of nanoparticles as radiation sensitizers for tumor cells and as radiation protectants for healthy tissue. In this investigation, cerium oxide nanoparticles (CNPs) obtained from the University of Central Florida's NanoScience Technology Center were studied for their protective effect to charged particle radiation in non-malignant breast cells, and for their sensitizing effect in breast and prostate cancer cell lines. These experiments were conducted at East Carolina University, where human cells were grown in the cell culture facility in the Department of Biology and then irradiated with energetic protons in the Accelerator Laboratory in the Department of Physics. Prior to irradiation, the cells were treated with distinct CNP preparations ranging in concentrations from 10 nanomolar to 10 micromolar, and cell viability was assessed using multiple assays post-irradiation. Radioprotection and radiosensitization were observed for several of the CNP treatments tested. Ultimately, the goal is to find a specific nanoparticle treatment that holds the synergistic effect of enhancing the rate of killing in tumor cells while simultaneously improving the survival of normal cells.
    URI
    http://hdl.handle.net/10342/6369
    Subject
     Proton Radiation; Clonogenic Assay 
    Date
    2017-07-17
    Citation:
    APA:
    Carlson, Nathan B. (July 2017). Protection and Sensitization of Human Cells to Proton Radiation by Cerium Oxide Nanoparticles (Doctoral Dissertation, East Carolina University). Retrieved from the Scholarship. (http://hdl.handle.net/10342/6369.)

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Carlson, Nathan B. Protection and Sensitization of Human Cells to Proton Radiation by Cerium Oxide Nanoparticles. Doctoral Dissertation. East Carolina University, July 2017. The Scholarship. http://hdl.handle.net/10342/6369. March 01, 2021.
    Chicago:
    Carlson, Nathan B, “Protection and Sensitization of Human Cells to Proton Radiation by Cerium Oxide Nanoparticles” (Doctoral Dissertation., East Carolina University, July 2017).
    AMA:
    Carlson, Nathan B. Protection and Sensitization of Human Cells to Proton Radiation by Cerium Oxide Nanoparticles [Doctoral Dissertation]. Greenville, NC: East Carolina University; July 2017.
    Collections
    • Dissertations
    • Physics
    Publisher
    East Carolina University

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback