Browsing Other Campus Research by Author "Abbott, Derek J."
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Cytokine-neuroantigen fusion proteins as a new class of tolerogenic, therapeutic vaccines for treatment of inflammatory demyelinating disease in rodent models of multiple sclerosis
Mannie, Mark D.; Blanchfield, J. Lori; Islam, S. M. Touhidul; Abbott, Derek J. (2012-08-20)Myelin-specific induction of tolerance represents a promising means to modify the course of autoimmune inflammatory demyelinating diseases such as multiple sclerosis (MS). Our laboratory has focused on a novel preclinical ... -
Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)
Abbott, Derek J.; Blanchfield, J. Lori; Martinson, David A; Russell, Sean C; Taslim, Najla; Curtis II, Alan Dale; Mannie, Mark D (2011-12-30)BACKGROUND: Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease in ...