Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)
Author
Abbott, Derek J; Blanchfield, J Lori; Martinson, David A; Russell, Sean C; Taslim, Najla; Curtis, Alan D; Mannie, Mark D
Abstract
BACKGROUND: Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease in chronic murine models of experimental autoimmune encephalomyelitis (EAE) and thus serve as potential therapeutic modalities for multiple sclerosis. RESULTS: A fusion protein comprised of murine GM-CSF as the N-terminal domain and the encephalitogenic MOG35-55 peptide as the C-terminal domain was tested as a tolerogenic, therapeutic vaccine (TTV) in the C57BL/6 model of EAE. Administration of GMCSF-MOG before active induction of EAE, or alternatively, at the onset of EAE blocked the development and progression of EAE. Covalent linkage of the GM-CSF and MOG35-55 domains was required for tolerogenic activity. Likewise, a TTV comprised of GM-CSF and PLP139-151 was a tolerogen in the SJL model of EAE. CONCLUSION: These data indicated that fusion proteins containing GM-CSF coupled to myelin auto-antigens elicit tolerance rather than immunity.
Date
2011-12-30
Citation:
APA:
Abbott, Derek J, & Blanchfield, J Lori, & Martinson, David A, & Russell, Sean C, & Taslim, Najla, & Curtis, Alan D, & Mannie, Mark D. (December 2011).
Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE).
BMC Immunology,
(12:72), p.1-18. Retrieved from
http://hdl.handle.net/10342/7744
MLA:
Abbott, Derek J, and Blanchfield, J Lori, and Martinson, David A, and Russell, Sean C, and Taslim, Najla, and Curtis, Alan D, and Mannie, Mark D.
"Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)". BMC Immunology.
12:72. (1-18.),
December 2011.
March 03, 2021.
http://hdl.handle.net/10342/7744.
Chicago:
Abbott, Derek J and Blanchfield, J Lori and Martinson, David A and Russell, Sean C and Taslim, Najla and Curtis, Alan D and Mannie, Mark D,
"Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)," BMC Immunology 12, no.
72 (December 2011),
http://hdl.handle.net/10342/7744 (accessed
March 03, 2021).
AMA:
Abbott, Derek J, Blanchfield, J Lori, Martinson, David A, Russell, Sean C, Taslim, Najla, Curtis, Alan D, Mannie, Mark D.
Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE). BMC Immunology.
December 2011;
12(72)
1-18. http://hdl.handle.net/10342/7744. Accessed
March 03, 2021.
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