Browsing Other Campus Research by Author "Keiper, Brett D."
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Cap-Independent mRNA Translation in Germ Cells
Keiper, Brett D. (2019-01-04)Cellular mRNAs in plants and animals have a 50-cap structure that is accepted as the recognition point to initiate translation by ribosomes. Consequently, it was long assumed that the translation initiation apparatus was ... -
Positive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity
Friday, Andrew J.; Keiper, Brett D. (2015)Ultimately, the production of new proteins in undetermined cells pushes them to new fates. Other proteins hold a stem cell in a mode of self-renewal. In germ cells, these decision-making proteins are produced largely from ... -
Spatial and temporal translational control of germ cell mRNAs mediated by the eIF4E isoform IFE-1
Friday, Andrew J.; Henderson, Melissa A.; Morrison, J. Kaitlin; Hoffman, Jenna L.; Keiper, Brett D. (2015)Regulated mRNA translation is vital for germ cells to produce new proteins in the spatial and temporal patterns that drive gamete development. Translational control involves the de-repression of stored mRNAs and their ... -
A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification
Lee, Myon-Hee; Mamillapalli, Srivalli Swathi; Keiper, Brett D.; Cha, Dong Seok (2016-02)Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. ...