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Correlation of pretreatment drug induced apoptosis in ovarian cancer cells with patient survival and clinical response
(2012-08-08)
This study was performed to determine if a chemotherapy-induced apoptosis assay (MiCK) could predict the best therapy for patients with ovarian cancer. A prospective, multi-institutional and blinded trial of the assay was ...
Phosphodiesterases regulate BAY 41-2272-induced VASP phosphorylation in vascular smooth muscle cells
(2012-02-07)
BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs). In this study, we elucidated mechanisms of action of BAY in its ...
Q-advanced models for tsunami and rogue waves
(2012-05-21)
A wavelet [subscript] Kq[/subscript] (t ) , that satisfies the q-advanced differential equation [superscript] K q [variant prime][/superscript] ( t ) =[subscript] K q[/subscript] (qt ) for q >1 , is used to model N-wave ...
Prey Responses to Predator Chemical Cues: Disentangling the Importance of the Number and Biomass of Prey Consumed
(2012-10)
To effectively balance investment in predator defenses versus other traits, organisms must accurately assess predation risk. Chemical cues caused by predation events are indicators of risk for prey in a wide variety of ...
Control of vascular smooth muscle cell growth by connexin 43
(2012-06-21)
Connexin 43 (Cx43), the principal gap junction protein in vascular smooth muscle cells (VSMCs), regulates movement of ions and other signaling molecules through gap junction intercellular communication (GJIC) and plays ...
Damage control surgery: It's evolution over the last 20 years
(2012-03-15)
In less than twenty years, what began as a concept for the treatment of exsanguinating truncal trauma patients has become the primary treatment model for numerous emergent, life threatening surgical conditions incapable ...
Millipede taxonomy after 250 years: classification and taxonomic practices in a mega-diverse yet understudied arthropod group.
(2012-03-15)
BACKGROUND: The arthropod class Diplopoda is a mega-diverse group comprising >12,000 described millipede species. The history of taxonomic research within the group is tumultuous and, consequently, has yielded a questionable ...
MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex
(2012-04)
Recently, strategies for acute myeloid leukemia (AML) therapy have been developed that target anti-apoptotic BCL2 family members using BH3-mimetic drugs such as ABT-737. Though effective against BCL2 and [BCL-X.sub.L], ...