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PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer
(2017-02-21)
Combined MAPK/PI3K pathway inhibition represents an attractive, albeit toxic, therapeutic strategy
in oncology. Since PTEN lies at the intersection of these two pathways, we investigated whether PTEN status determines the ...
miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1)
(2017-12-21)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is etiologically associated with all forms of Kaposi’s sarcoma worldwide. Little is currently known about the role of microRNAs (miRNAs) in KSHV entry.
We recently demonstrated ...
Potential Mechanisms and Functions of Intermittent Neural Synchronization
(2017-05-30)
Neural synchronization is believed to play an important role in different brain functions. Synchrony in cortical and subcortical circuits is frequently variable in time and not perfect. Few long intervals of desynchronized ...
Oral microbe-host interactions: influence of β-glucans on gene expression of inflammatory cytokines and metabolome profile
(2017-03-07)
Background: The aim of this study was to evaluate the effects of β-glucan on the expression of inflammatory mediators and metabolomic profile of oral cells [keratinocytes (OBA-9) and fibroblasts (HGF-1) in a dual-chamber ...
Nearshore mixing and nutrient delivery along the western Antarctic Peninsula
(2017-10)
The surface waters of the Southern Ocean play a key role in the global climate and carbon cycles by
promoting growth of some of the world’s largest phytoplankton blooms. Several studies have emphasized the
importance of ...
Pathology Informatics Essentials for Residents: A Flexible Informatics Curriculum Linked to Accreditation Council for Graduate Medical Education Milestones
(2017-01)
Context.—Recognition of the importance of informatics to the practice of pathology has surged. Training residents in pathology informatics has been a daunting task for most residency programs in the United States because ...
Una adelfa en tierras extrañas emblemática y misoginia en la "Comedia famosa de los guanches de Tenerife y conquista de Canaria
(2017)
In his play Los guanches de Tenerife Lope de Vega resorts to one of the emblems included in his friend Hernando de Soto’s Emblemas moralizadas (1599) to dramatize the encounter between Guanches and Spaniards and to represent ...
Identifying Keys to Success in Innovative Teaching: Student Engagement and Instructional Practices as Predictors of Student Learning in a Course Using a Team- Based Learning Approach
(2017-09)
When implementing innovative teaching techniques, instructors often seek to gauge the success of their methods. Proposing one approach to assessing classroom innovation, this study examines the ability of students’ ratings ...
It’s not what you expect: feedback negativity is independent of reward expectation and affective responsivity in a non-probabilistic task
(2017-03)
ERP studies commonly utilize gambling-based reinforcement tasks to elicit feedback negativity (FN) responses. This study used a pattern learning task in order to limit gambling-related fallacious reasoning and possible ...
MicroRNA expression profiles during cotton (Gossypium hirsutum L) fiber early development
(2017-03-22)
The role of microRNAs (miRNAs) during cotton fiber development remains unclear. Here, a total of
54 miRNAs belonging to 39 families were selected to characterize miRNA regulatory mechanism in eight different fiber development ...