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Now showing items 131-140 of 173
The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development
(2018-10-10)
The transition of rod precursor cells to post-mitotic rod photoreceptors can be promoted by extrinsic factors such as insulin-like growth factor 1 (IGF- 1), which regulates phosphatidylinositide concentration, and consequently ...
Temperature Influences Herbivory and Algal Biomass in the Galápagos Islands
(2018-08-17)
Temperature can influence trophic interactions via predictable effects on the metabolism of ecothermic consumers. Under some conditions, warming should increase top–down control, and trophic transfer rates, leading to ...
The Continuing Fellowship Conundrum
(2018-02-11)
The debate for a fair, equitable, and reasonable pathology fellowship application and selection process has been an ongoing issue with ebb and flow over approximately the past 10 years. The authors of this commentary have ...
Temporal dynamics of genetic clines of invasive European green crab (Carcinus maenas) in eastern North America
(2018-06-08)
Two genetically distinct lineages of European green crabs (Carcinus maenas) were in- dependently introduced to eastern North America, the first in the early 19th century and the second in the late 20th century. These ...
Adolescent smoking: The relationship between cigarette consumption and BMI
(2018-12-07)
Background:Studies relating cigarette smoking and body weight yield conflicting results. Weight-lowering effects in women and men have been associated with smoking, however, no effects on weight have been proven.This study ...
The Impact of Locoregional Therapy in Nonmetastatic Inflammatory Breast Cancer: A Population-Based Study
(2018-06-03)
Background. Inflammatory breast cancer (IBC) is a rare but most aggressive breast cancer subtype. The impact of locoregional therapy on survival in IBC is controversial. Methods. Patients with nonmetastatic IBC between ...
The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids
(2018-11-06)
Spermatogenesis is a complex and dynamic cellular differentiation process critical to male reproduc- tion and sustained by spermatogonial stem cells (SSCs). Although patterns of gene expression have been described for ...
β-catenin nuclear translocation induced by HIF-1α overexpression leads to the radioresistance of prostate cancer
(2018-03-16)
Hypoxia-inducible factor-1α (HIF-1α) is known to play crucial roles in tumor radioresistance; however, the molecular mechanisms responsible for the promotion of tumor radioresistance by HIF-1α remain unclear. β-catenin is ...
Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update
(2018-06-26)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood malignancy that arises from the clonal expansion of transformed T-cell precursors. Although T-ALL prognosis has significantly improved due to the development ...
Therapeutic targeting of CK2 in acute and chronic leukemias
(2018-01)
Phosphorylation can regulate almost every property of a protein and is involved in all fundamental cellular processes. Thus, proper regulation of phosphorylation events is critical to the homeostatic functions of cell ...