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Imaging of morphological and biochemical hallmarks of apoptosis with optimized optogenetic tools
(2019-10-03)
Creation of optogenetic switches for specific activation of cell death pathways can provide insights into apoptosis and could also form a basis for noninvasive, next-generation therapeutic strategies. Previous work has ...
Life in a contaminant milieu: PPCP mixtures generate unpredictable outcomes across trophic levels and life stagest
(2019-12-05)
Nearly all aquatic ecosystems are affected by sublethal levels of anthropogenic chemical contamination, but other agents of large‐scale anthropogenic disruption of ecosystems have received more attention. Consequently, ...
Customer Reviews Analysis With Deep Neural Networks for E-Commerce Recommender Systems
(2019-08-26)
An essential prerequisite of an effective recommender system is providing helpful information
regarding users and items to generate high-quality recommendations. Written customer review is a rich
source of information ...
Construction of realistic hybrid computational fetal phantoms from radiological images in three gestational ages for radiation dosimetry applications
(2019-10-10)
Radiation exposure and associated radiation risks are major concerns for fetal development for
pregnant patients who undergo radiation therapy or diagnostic imaging procedures. In order to
accurately estimate the radiation ...
Circular Single-Stranded DNA Virus (Microviridae: Gokushovirinae: Jodiemicrovirus) Associated with the Pathobiome of the Flat-Back Mud Crab, Eurypanopeus depressus
(2019-11-21)
A single-stranded DNA (ssDNA) virus is presented from a metagenomic data set derived from Alphaproteobacteria-infected hepatopancreatic tissues of the crab Eurypanopeus depressus. The circular virus genome (4,768 bp) encodes ...
Alternative splicing of UCP1 by non-cell-autonomous action of PEMT
(2019-11-08)
Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Mice lacking ...
Interventions to improve sarcopenia in cirrhosis: A systematic review
(2019-01-26)
BACKGROUND:
Sarcopenia, i.e., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it ...
Isolated neutropenia as a rare but serious adverse event secondary to immune checkpoint inhibition
(2019-07-05)
Background
Compared to conventional chemotherapy, Immune checkpoint inhibitors (ICI) are known to have a distinct toxicity profile commonly identified as immune-related adverse events (irAEs). These irAEs that are believed ...
Species-Specific Conservation of Linear Antigenic Sites on Vaccinia Virus A27 Protein Homologs of Orthopoxviruses
(2019-05-29)
The vaccinia virus (VACV) A27 protein and its homologs, which are found in a large number of members of the genus Orthopoxvirus (OPXV), are targets of viral neutralization by host antibodies. We have mapped six binding ...
Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes
(2019-03-21)
The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r. In this study we ...