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Palmitate-induced ER stress and inhibition of protein synthesis in cultured myotubes does not require Toll-like receptor 4
(2018-01-12)
Saturated fatty acids, such as palmitate, are elevated in metabolically dysfunctional condi- tions like type 2 diabetes mellitus. Palmitate has been shown to impair insulin sensitivity and suppress protein synthesis while ...
The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy
(2013-08-24)
Hepatocellular carcinoma (HCC) is one of the most common potentially lethal human malignancies worldwide. Advanced or recurrent HCC is frequently resistant to conventional chemotherapeutic agents and radiation. Therefore, ...
The association between trust in health care providers and medication adherence among Black women with hypertension
(2013-12-05)
Background: Black women have the highest prevalence of hypertension in the world. Reasons for this disparity are poorly understood. The historical legacy of medical maltreatment of Blacks in the U.S. provides some insight ...
Telephone surveys underestimate cigarette smoking among African-Americans
(2013-09-25)
Background. This study tested the hypothesis that data from random digit-dial telephone surveys underestimate the prevalence of cigarette smoking among African-American adults. Method. A novel, community-sampling method ...
Monitoring Rice Phenology Based on Backscattering Characteristics of Multi-Temporal RADARSAT-2 Datasets
(2018-02-23)
Accurate estimation and monitoring of rice phenology is necessary for the management and yield prediction of rice. The radar backscattering coefficient, one of the most direct and accessible parameters has been proved to ...
Vascular tissue contractility changes following late gestational exposure to multi-walled carbon nanotubes or their dispersing vehicle in Sprague Dawley rats
(2014-04-20)
Multi-walled carbon nanotubes (MWCNTs) are increasingly used in industry and in nanomedicine raising safety concerns, especially during unique life-stages such as pregnancy. We hypothesized that MWCNT exposure during ...
miRNA-23a/27a attenuates muscle atrophy and renal fibrosis through muscle-kidney crosstalk
(2018-03-26)
Background The treatment of muscle wasting is accompanied by benefits in other organs, possibly resulting from muscle– organ crosstalk. However, how the muscle communicates with these organs is less understood. Two microRNAs ...
A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease
(2013-02)
Background
Platelet activation has been implicated in the pathogenesis of sickle cell disease (SCD) suggesting antiplatelet agents may be therapeutic. To evaluate the safety of prasugrel, a thienopyridine antiplatelet ...
VASP activation via the Gα13/RhoA/PKA pathway mediates cucurbitacin-B-induced actin aggregation and cofilin-actin rod formation
(2014-04-01)
Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis. However, the underlying molecular mechanism ...
WalkMore: A randomized controlled trial of pedometer-based interventions differing on intensity messages
(2014-02-15)
Pedometer-based programs have elicited increased walking behaviors associated with improvements in blood pressure in sedentary/low active postmenopausal women, a population at increased risk of cardiovascular disease. Such ...