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Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells
(2017-08-24)
A critical problem in leukemia as well as other cancer therapies is the development of chemotherapeutic drug-resistance. We have developed models of hematopoietic drug resistance that are based on expression of dominant-negative ...
The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic Response
(2019-05-06)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer that comprises 10–15% of pediatric and ~25% of adult ALL cases. Although the curative rates have significantly improved over the past 10 years, ...
Timing of Esophagectomy after Neoadjuvant Chemoradiation Therapy Affects the Incidence of Anastomotic Leaks
(2019-02-05)
Background:
Neoadjuvant chemoradiation therapy (nCRT) has become the standard of care for esophageal cancer patients prior to esophagectomy. However, the optimal timing for surgery after completion of nCRT remains ...
Towards measuring resilience of flood-prone communities: a conceptual framework
(2019-06-17)
Community resilience has become an important
policy and research concept for understanding and addressing the challenges associated with the interplay of climate
change, urbanization, population growth, land use, ...
The validity, reliability and minimal clinically important difference of the patient specific functional scale in snake envenomation
(2019-03-05)
Objective:
Valid, reliable, and clinically relevant outcome measures are necessary in clinical studies of snake envenomation. The aim of this study was to evaluate the psychometric (validity and reliability) and clinimetric ...
The effects of temperature on Bosmina longirostris susceptibility to microcystin-LR acute toxicity
(2019-07-09)
Harmful algal blooms are an ongoing threat to many aquatic systems throughout the world. In the Chowan River, North Carolina, the frequency of toxin producing Microcystis aeruginosa blooms has increased since 1975 along ...
Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers
(2019-01-10)
Characterization of small oligomers formed at an early stage of amyloid formation is critical to
understanding molecular mechanism of pathogenic aggregation process. Here we identifed and
characterized cytotoxic oligomeric ...
TOXIFY: a deep learning approach to classify animal venom proteins
(2019-06-28)
In the era of Next-Generation Sequencing and shotgun proteomics, the sequences
of animal toxigenic proteins are being generated at rates exceeding the pace of
traditional means for empirical toxicity verification. To ...
Is Motorized Treadmill Running Biomechanically Comparable to Overground Running? A Systematic Review and Meta-Analysis of Cross-Over Studies
(2019-12-04)
Background Treadmills are often used in research, clinical practice, and training. Biomechanical investigations comparing treadmill and overground running report inconsistent findings. Objective This study aimed at comparing ...
Phylogenomic Reconstruction of the Neotropical Poison Frogs (Dendrobatidae) and Their Conservation
(2019-01-29)
The evolutionary history of the Dendrobatidae, the charismatic Neotropical poison frog family, remains in flux, even after a half-century of intensive research. Understanding the evolutionary relationships between dendrobatid ...