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The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease
(2018-02-26)
The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it serves as a co-chaperone with heat shock proteins ...
Concurrent validity of skin carotenoid status as a concentration biomarker of vegetable and fruit intake compared to multiple 24-h recalls and plasma carotenoid concentrations across one year: a cohort study
(2019-10-30)
Background
Biological markers of vegetable and fruit (VF) intake are needed both for nutrition surveillance and for the evaluation of nutrition interventions. Optically assessed skin carotenoid status (SCS) has been ...
Evidence for acquisition of virulence effectors in pathogenic chytrids
(2011-07-08)
Background
The decline in amphibian populations across the world is frequently linked to the infection of the chytrid fungus Batrachochytrium dendrobatidis (Bd). This is particularly perplexing because Bd was only recently ...
The National Clinical Assessment Tool for Medical Students in the Emergency Department (NCAT-EM)
(2018-01)
Introduction: Clinical assessment of medical students in emergency medicine (EM) clerkships is
a highly variable process that presents unique challenges and opportunities. Currently, clerkship directors use institution-specific ...
Quantitative assessment of image motion blur in diffraction images of moving biological cells
(2016-02)
Motion blur (MB) presents a significant challenge for obtaining high-contrast image data from biological cells with a polarization diffraction imaging flow cytometry (p-DIFC) method. A new p-DIFC experimental system has ...
Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells
(2017-01-27)
Acidosis commonly exists in the tissue microenvironment of various pathophysiological conditions such as tumors, inflammation, ischemia, metabolic disease, and respiratory disease. For instance, the tumor microenvironment ...
The Bee Microbiome: Impact on Bee Health and Model for Evolution and Ecology of Host-Microbe Interactions
(2016)
As pollinators, bees are cornerstones for terrestrial ecosystem stability and key components in agricultural productivity. All animals, including bees, are associated with a diverse community of microbes, commonly referred ...
A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women
(2017-03-02)
SNP rs7903146 in the Wnt pathway’s TCF7L2 gene is the variant most significantly associ- ated with type 2 diabetes to date, with associations observed across diverse populations. We sought to determine whether variants in ...
What factors influence older people’s intention to enrol in nursing homes? A cross-sectional observational study in Shanghai, China
(2018-09-05)
Objectives Given the increasing need of long-term care and the low occupancy rate of nursing homes in Shanghai, this study attempts to explore what factors influence older people’s intention to enrol in nursing homes.
Design ...