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Microvascular Endothelial Dysfunction in Sedentary, Obese Humans Is Mediated by NADPH Oxidase Influence of Exercise Training
(2016)
Objective—The objectives of this study were to determine the impact of in vivo reactive oxygen species (ROS) on
microvascular endothelial function in obese human subjects and the efficacy of an aerobic exercise intervention ...
Hypoxia inducible factor-1α-dependent epithelial to mesenchymal transition under hypoxic conditions in prostate cancer cells
(2016)
Prostate cancer is the most commonly diagnosed
cancer in men and the second leading cause of cancer death.
Hypoxia is an environmental stimulus that plays an important
role in the development and cancer progression ...
Rapid Evolution of Manifold CRISPR Systems for Plant Genome Editing
(2016-11-14)
Advanced CRISPR-Cas9 based technologies first validated in mammalian cell systems
are quickly being adapted for use in plants. These new technologies increase
CRISPR-Cas9’s utility and effectiveness by diversifying ...
Quantitative assessment of image motion blur in diffraction images of moving biological cells
(2016-02)
Motion blur (MB) presents a significant challenge for obtaining high-contrast image data from biological cells with a polarization diffraction imaging flow cytometry (p-DIFC) method. A new p-DIFC experimental system has ...
Acid ceramidase is upregulated in AML and represents a novel therapeutic target
(2016-12-13)
There is an urgent unmet need for new therapeutics in acute myeloid leukemia (AML) as standard therapy has not changed in the past three decades and outcome remains poor for most patients. Sphingolipid dysregulation through ...
A Sparsity-Based InSAR Phase Denoising Algorithm Using Nonlocal Wavelet Shrinkage
(2016-10-10)
An interferometric synthetic aperture radar (InSAR) phase denoising algorithm using the local sparsity of wavelet coefficients and nonlocal similarity of grouped blocks was developed. From the Bayesian perspective, the ...
EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy
(2016)
Vici syndrome is a progressive neurodevelopmental multisystem disorder due to recessive mutations in the key autophagy gene EPG5. We report genetic, clinical, neuroradiological, and neuropathological features of 50 children ...
Diffusion and perfusion weighted magnetic resonance imaging for tumor volume definition in radiotherapy of brain tumors
(2016-09-21)
Accurate target volume delineation is crucial for the radiotherapy of tumors. Diffusion and perfusion magnetic resonance imaging (MRI) can provide functional information about brain tumors, and they are able to detect tumor ...
Driving innovation through big open linked data (BOLD): Exploring antecedents using interpretive structural modelling
(2016-07-13)
Innovation is vital to find new solutions to prob- lems, increase quality, and improve profitability. Big open linked data (BOLD) is a fledgling and rapidly evolving field that creates new opportunities for innovation. ...
Examining signals of trust in criminal markets online
(2016-09-14)
This study examines the signals of trust in stolen data advertisements by analysing the structural and situational factors that influence the type of feedback sellers receive. Specifically, this article explores the factors ...