Now showing items 21-30 of 164
TNM cancer staging: can it help develop a novel staging system for type 2 diabetes?
Type 2 diabetes (DM2) constitutes 90%–95% of the diabetes cases and is increasing at an alarming rate in the world. The Centers for Disease Control and Prevention (CDC) estimates that more than 29 million people in the ...
Profile of Public Health Leadership
N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression
The mRNA modification N6-methyladenosine (m6A) is involved in many post-transcriptional regulatory processes including mRNA stability and translational efficiency. However, it is also imperative to correlate these processes ...
Emerging role of immune checkpoint blockade in pancreatic cancer
Immune checkpoint blockade (ICB) with programmed cell death protein-1(PD-1)/programmed death ligand -1(PD-L1) antibodies has revolutionized the management of several cancers, especially non-small cell lung cancer, melanoma, ...
Lack of complex type N-glycans lessens aberrant neuronal properties
Modifications in surface glycans attached to proteins via N-acetylglucosamine-β1-Nasparagine linkage have been linked to tumor development and progression. These modifications include complex N-glycans with high levels of ...
Sensor selection to improve estimates of particulate matter concentration from a low-cost network
Deployment of low-cost sensors in the field is increasingly popular. However, each sensor requires on-site calibration to increase the accuracy of the measurements. We established a laboratory method, the Average Slope ...
Step-wise evolution of complex chemical defenses in millipedes: a phylogenomic approach
With fossil representatives from the Silurian capable of respiring atmospheric oxygen, millipedes are among the oldest terrestrial animals, and likely the first to acquire diverse and complex chemical defenses against ...
Stem cell models of human synapse development and degeneration
Many brain disorders exhibit altered synapse formation in development or syn- apse loss with age. To understand the complexities of human synapse development and degeneration, scientists now engineer neurons and brain ...
One-Year Follow-Up Examination of the Impact of the North Carolina Healthy Food Small Retailer Program on Healthy Food Availability, Purchases, and Consumption
We examined the short-term impact of the North Carolina Healthy Food Small Retailer Program (HFSRP), a legislatively appropriated bill providing funding up to $25,000 to small food retailers for equipment to stock and ...