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Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system
(2011-06-20)
Adipocyte infiltration of the musculoskeletal system is well recognized as a hallmark of aging, obesity, and type 2 diabetes. Intermuscular adipocytes might serve as a benign storage site for surplus lipid or play a role ...
Is there a metabolic program in the skeletal muscle of obese individuals?
(2011-04-26)
Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are ...