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    THE RELATIONSHIP BETWEEN LACTATE, MITOCHONDRIA, AND PEROXISOMES IN HUMAN SKELETAL MUSCLE

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    DUNBAR-HONORSTHESIS-2018.pdf (269.9Kb)

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    Author
    Dunbar, Keith Winston
    Abstract
    Human metabolism is a complex mechanism involving many interdependent parts. The purpose of this paper is to explore the relationship or lack thereof between lactate, mitochondria, and peroxisomes in human skeletal muscle. We accomplished this purpose by analyzing the skeletal muscle tissue of forty-four pre-menopausal women, in order to evaluate their levels of lactate, mitochondria, and peroxisomes. Through Western Blot analysis, we found that subjects with diabetes possessed much higher levels of PEX19, a peroxisomal protein. COX IV, a mitochondrial protein, was also found to be elevated in lean subjects. Lastly, lactate and PEX19 also seemed to interact in the subjects, as patients with higher lactate levels also possessed higher levels of PEX19. Through this data we can see that there is a clearly a relationship between the mitochondria, peroxisome, and lactate, which still needs to be further explored by more research.
    URI
    http://hdl.handle.net/10342/6883
    Subject
     Lactate, Mitochondria, Peroxisomes; Human Skeletal Muscle, Metabolism 
    Date
    2018-05-03
    Citation:
    APA:
    Dunbar, Keith Winston. (May 2018). THE RELATIONSHIP BETWEEN LACTATE, MITOCHONDRIA, AND PEROXISOMES IN HUMAN SKELETAL MUSCLE (Honors Thesis, East Carolina University). Retrieved from the Scholarship. (http://hdl.handle.net/10342/6883.)

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    MLA:
    Dunbar, Keith Winston. THE RELATIONSHIP BETWEEN LACTATE, MITOCHONDRIA, AND PEROXISOMES IN HUMAN SKELETAL MUSCLE. Honors Thesis. East Carolina University, May 2018. The Scholarship. http://hdl.handle.net/10342/6883. April 19, 2021.
    Chicago:
    Dunbar, Keith Winston, “THE RELATIONSHIP BETWEEN LACTATE, MITOCHONDRIA, AND PEROXISOMES IN HUMAN SKELETAL MUSCLE” (Honors Thesis., East Carolina University, May 2018).
    AMA:
    Dunbar, Keith Winston. THE RELATIONSHIP BETWEEN LACTATE, MITOCHONDRIA, AND PEROXISOMES IN HUMAN SKELETAL MUSCLE [Honors Thesis]. Greenville, NC: East Carolina University; May 2018.
    Collections
    • Honors College
    • Kinesiology
    Publisher
    East Carolina University

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